Clinical efficacy and complications of three-dimensional reconstruction technique-assisted REA in the treatment of&nbsp;NSLCL patients

Yang Bin, Zhao Hailong, Zheng Fengchang, Wei Zheng, Sun Peng, Guo Tao, Yang Weilin

doi:10.13418/j.issn.1001-165x.2026.2.11

2026 , Vol. 44 >Issue 2: 194 - 200

DOI: https://doi.org/10.13418/j.issn.1001-165x.2026.2.11

Clinical efficacy and complications of three-dimensional reconstruction technique-assisted REA in the treatment of NSLCL patients

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Department of Thoracic Surgery, Gansu Provincial Cancer Hospital, Lanzhou 730050, Gansu Province, China

Received date: 2025-12-25

Online published: 2026-04-16

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Abstract

Objective To investigate the clinical efficacy and safety of three-dimensional reconstruction technique-assisted radiofrequency ablation (REA) of lung tumors in the treatment of patients with non-small cell lung cancer with with spinal invasion (NSLCL). Methods A total of 110 patients with NSLCL were divided into a three-dimensional reconstruction planning group (51 cases, three-dimensional reconstruction technique-assisted REA) and a two-dimensional CT planning group (59 cases, two-dimensional CT planning-assisted REA) based on different treatment regimens. The surgery-related indicators, pain visual analogue scale (VAS) score, tumor markers, functional recovery, quality of life, tumor ablation target volume at 3 months after surgery and incidence rates of surgery-related complications were compared between the two groups. Results Compared with two-dimensional CT planning group, the CT scan frequency and intraoperative blood loss volume in three-dimensional reconstruction planning group were less, and the needle insertion time, surgical time and postoperative hospital stay were shorter (P<0.05). The VAS scores in three-dimensional reconstruction planning group at 6 and 24 hours after surgery were lower than those in two-dimensional CT planning group (P<0.05). At 1 month and 3 months after surgery, the levels of serum carbohydrate antigen 125 (CA125), carcinoembryonic antigen (CEA) and squamous cell carcinoma antigen (SCC-Ag) in three-dimensional reconstruction planning group were lower than those in two-dimensional CT planning group (P<0.05), and the Karnofsky performance status (KPS) score and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 (EORTC QLQ-C30) score were better compared with two-dimensional CT planning group (P<0.05). At 3 months after surgery, the tumor ablation target volume in three-dimensional reconstruction planning group was smaller than that in two-dimensional CT planning group (P<0.05). The incidence rates of complications were significantly lower in three-dimensional reconstruction planning group than those in two-dimensional CT planning group (P<0.05). Conclusions Three-dimensional reconstruction technique-assisted REA in the treatment of NSLCL can effectively control tumor progression, promote postoperative recovery, improve the quality of life and reduce the risk of complications, with important clinical application value.

Key words： Non-small cell lung cancer; Spinal invasion; Three-dimensional reconstruction; Radiofrequency ablation; Tumor markers

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Yang Bin, Zhao Hailong, Zheng Fengchang, Wei Zheng, Sun Peng, Guo Tao, Yang Weilin . Clinical efficacy and complications of three-dimensional reconstruction technique-assisted REA in the treatment of NSLCL patients[J]. Chinese Journal of Clinical Anatomy, 2026 , 44(2) : 194 -200 . DOI: 10.13418/j.issn.1001-165x.2026.2.11

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