Clinical efficacy and complications of three-dimensional reconstruction technique-assisted REA in the treatment of&nbsp;NSLCL patients

doi:10.13418/j.issn.1001-165x.2026.2.11

PDF(1303 KB)

Chinese Journal of Clinical Anatomy ›› 2026, Vol. 44 ›› Issue (2) : 194-200. DOI: 10.13418/j.issn.1001-165x.2026.2.11

Clinical efficacy and complications of three-dimensional reconstruction technique-assisted REA in the treatment of NSLCL patients

Yang Bin, Zhao Hailong, Zheng Fengchang, Wei Zheng, Sun Peng, Guo Tao, Yang Weilin*

Author information +

History +

Abstract

Objective To investigate the clinical efficacy and safety of three-dimensional reconstruction technique-assisted radiofrequency ablation (REA) of lung tumors in the treatment of patients with non-small cell lung cancer with with spinal invasion (NSLCL). Methods A total of 110 patients with NSLCL were divided into a three-dimensional reconstruction planning group (51 cases, three-dimensional reconstruction technique-assisted REA) and a two-dimensional CT planning group (59 cases, two-dimensional CT planning-assisted REA) based on different treatment regimens. The surgery-related indicators, pain visual analogue scale (VAS) score, tumor markers, functional recovery, quality of life, tumor ablation target volume at 3 months after surgery and incidence rates of surgery-related complications were compared between the two groups. Results Compared with two-dimensional CT planning group, the CT scan frequency and intraoperative blood loss volume in three-dimensional reconstruction planning group were less, and the needle insertion time, surgical time and postoperative hospital stay were shorter (P<0.05). The VAS scores in three-dimensional reconstruction planning group at 6 and 24 hours after surgery were lower than those in two-dimensional CT planning group (P<0.05). At 1 month and 3 months after surgery, the levels of serum carbohydrate antigen 125 (CA125), carcinoembryonic antigen (CEA) and squamous cell carcinoma antigen (SCC-Ag) in three-dimensional reconstruction planning group were lower than those in two-dimensional CT planning group (P<0.05), and the Karnofsky performance status (KPS) score and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 (EORTC QLQ-C30) score were better compared with two-dimensional CT planning group (P<0.05). At 3 months after surgery, the tumor ablation target volume in three-dimensional reconstruction planning group was smaller than that in two-dimensional CT planning group (P<0.05). The incidence rates of complications were significantly lower in three-dimensional reconstruction planning group than those in two-dimensional CT planning group (P<0.05). Conclusions Three-dimensional reconstruction technique-assisted REA in the treatment of NSLCL can effectively control tumor progression, promote postoperative recovery, improve the quality of life and reduce the risk of complications, with important clinical application value.

Key words

Non-small cell lung cancer / Spinal invasion / Three-dimensional reconstruction / Radiofrequency ablation / Tumor markers

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

Yang Bin, Zhao Hailong, Zheng Fengchang, Wei Zheng, Sun Peng, Guo Tao, Yang Weilin. Clinical efficacy and complications of three-dimensional reconstruction technique-assisted REA in the treatment of NSLCL patients[J]. Chinese Journal of Clinical Anatomy. 2026, 44(2): 194-200 https://doi.org/10.13418/j.issn.1001-165x.2026.2.11

References

[1] 冷傲, 孟令志, 李佳乘, 等. 非小细胞肺癌脊柱转移患者的术后生存期与相关因素分析[J].中国脊柱脊髓杂志, 2024, 34(12): 1260-1266. DOI:10.3969/j.issn.1004-406X.2024.12.05.
Leng A, Meng LZ, Li JC, et al. Analysis of postoperative survival and risk factors in patients with spinal metastases from non-small cell lung cancer[J]. Chinese Journal of Spine and Spinal Cord, 2024, 34(12): 1260-1266. DOI:10.3969/j.issn.1004-406X.2024.12.05.
[2] 胡雪艳, 孟凡亮, 董娟娟. 不同病理分型的初治非小细胞肺癌骨转移患者的预后分析[J]. 实用医学杂志, 2024, 40(16): 2316-2325. DOI: 10.3969/j.issn.1006-5725.2024.16.019.
Hu XY, Meng FL, Dong JJ. Prognostic analysis of patients with bone metastases from primary non-small cell lung cancer with different pathologic staging[J]. The Journal of Practical Medicine, 2024, 40(16): 2316-2325. DOI:10.3969/j.issn.1006-5725.2024.16.019.
[3] Wang K, Jiang L, Hu A, et al. Vertebral-specific activation of the CX3CL1/ICAM-1 signaling network mediates non-small-cell lung cancer spinal metastasis by engaging tumor cell-vertebral bone marrow endothelial cell interactions[J]. Theranostics, 2021, 11(10): 4770-4789. DOI:10.7150/thno.54235.
[4] Zhou X, Li H, Qiao Q, et al. CT-guided percutaneous minimally invasive radiofrequency ablation for the relief of cancer related pain from metastatic non-small cell lung cancer patients: a retrospective study[J]. Ann Palliat Med, 2021, 10(2): 1494-1502. DOI:10.21037/apm-19-474.
[5] 刘继伟, 杨瑞. 高分辨率CT引导下射频消融治疗早期非小细胞肺癌研究[J].实用放射学杂志, 2023, 39(6): 1001-1004. DOI:10.3969/j.issn.1002-1671.2023.06.032.
Liu JW, Yang R. High resolution CT-guided radiofrequency ablation in treatment for early non-small cell lung cancer[J]. Journal of Practical Radiology, 2023, 39(6): 1001-1004. DOI:10.3969/j.issn.1002-1671. 2023.06.032.
[6] You X, Huang B, Chen J, et al. Application of respiratory sensing technique in CT-guided radiofrequency ablation of liver malignancies[J]. J Cancer Res Ther, 2023, 19(4): 1019-1023. DOI:10.21037/apm-19-474.
[7] Tordjman M, Perronne L, Madelin G, et al. CT-guided radiofrequency ablation for osteoid osteomas: a systematic review[J]. Eur Radiol, 2020, 30(11): 5952-5963. DOI:10.1007/s00330-020-06970-y.
[8] Wang Y, Zhao Z, Wang W, et al. Safety and efficacy of CT-guided percutaneous radiofrequency ablation for non-small cell lung cancer: a single-center, single-arm analysis[J]. Lasers Med Sci, 2024, 39(1): 199. DOI:10.1007/s10103-024-04153-5.
[9] Gong Y, Tang Y, Geng Y, et al. Comparative safety and effectiveness of ultrasound-guided radiofrequency ablation combined with preoperative three-dimensional reconstruction versus surgical resection for solitary hepatocellular carcinoma of 3-5 cm[J]. J Cancer, 2019, 10(22): 5568-5574. DOI:10.7150/jca.32342.
[10]Kock ID, Mirhosseini M, Lau F, et al. Conversion of Karnofsky performance status (KPS) and eastern cooperative oncology group performance status (ECOG) to Palliative performance scale (PPS), and the interchangeability of PPS and KPS in prognostic tools[J]. J Palliat Care, 2013, 29(3): 163-169.
[11]Cocks K, Wells JR, Johnson C, et al. Content validity of the EORTC quality of life questionnaire QLQ-C30 for use in cancer[J]. Eur J Cancer, 2023, 178(1): 128-138. DOI:10.1016/j.ejca.2022.10.026.
[12]Hireche K, Moqaddam M, Lonjon N, et al. Combined video-assisted thoracoscopy surgery and posterior midline incision for en bloc resection of non-small-cell lung cancer invading the spine[J]. Interact Cardiovasc Thorac Surg, 2022, 34(1): 74-80. DOI:10.1093/icvts/ivab215.
[13]Liang H, Chen Q, Hu Z, et al. Siglec15 facilitates the progression of non-small cell lung cancer and is correlated with spinal metastasis[J]. Ann Transl Med, 2022, 10(6): 281. DOI:10.21037/atm-22-764.
[14]Yao Y, Zhu X, Zhang N, et al. Microwave ablation versus radiofrequency ablation for treating spinal metastases[J]. Medicine (Baltimore), 2023, 102(25): e34092. DOI:10.1097/MD.00000000000 34092.
[15]刘继伟, 王肖辉, 杨瑞, 等. HRCT引导下射频消融治疗早期非小细胞肺癌的并发症[J]. 临床放射学杂志, 2021, 40(11): 2192-2195.
Liu JW, Wang XH, Yang R, et al. Complications of HRCT-guided radiofrequency ablation in treatment of early non-small cell lung cancer[J]. Journal of Clinical Radiology, 2021, 40(11): 2192-2195.
[16]Du H, Tan X, Cheng L, et al. Application and evaluation of a 64-Slice CT three-dimensional fusion technique in the determination of the effective ablation margin after radiofrequency ablation of hepatocellular carcinoma[J]. Comput Math Methods Med, 2022, 2022: 6898233. DOI: 10.1155/2022/6898233.
[17]Liu Y, Meng S, Wei M, et al. Reconstruction of three-dimensional models for complex female pelvic tumors[J]. Int J Gynaecol Obstet, 2022, 157(3): 747-749. DOI: 10.1002/ijgo.14120.
[18]You YH, Zhao D, Huang QB, et al. Application of mimics medical 21.0 software in thoracoscopic anatomical sublobectomy[J]. Minerva Surg, 2022, 77(3): 221-228. DOI: 10.23736/S2724-5691.21.08927-9.
[19]Hu X, Lu M, Wang Y, et al. Advanced pelvic girdle reconstruction with three dimensional-printed custom hemipelvic endoprostheses following pelvic tumour resection[J]. Int Orthop, 2024, 48(8): 2217-2231. DOI: 10.1007/s00264-024-06207-3.
[20]Hsu HH, Wong CE, Lee JW, et al. Computer-aided three-dimensional virtual surgical planning in complex skull base reconstruction for sphenoid wing dysplasia in neurofibromatosis type 1[J]. J Craniofac Surg, 2021, 32(7): 2539-2541. DOI: 10.1097/SCS.0000000000007952.
[21]张雯雯, 王宏光, 史宪杰, 等. 三维重建术前规划在腹腔镜超声引导的肝癌射频消融术中的应用探讨[J]. 中华外科杂志, 2016, 54(9): 692-699. DOI: 10.3760/cma.j.issn.0529-5815.2016.09.009.
Zhang WW, Wang HG, Shi XJ, et al. Significance of three-dimensional reconstruction as a method of preoperative planning of laparoscopic radiofrequency ablation[J]. Chinese Journal of Surgery, 2016, 54(9): 692-699. DOI: 10.3760/cma.j.issn.0529-5815.2016.09.009.
[22]陈程, 刘慧. 局部介入治疗联合立体定向放疗对肺腺癌脊柱转移瘤患者的疼痛缓解疗效分析[J].介入放射学杂志, 2025, 34(8): 851-855. DOI: 10.3969/j.issn.1008-794X.2025.08.009.
Chen C, Liu H. Local interventional therapy combined with stereotactic radiotherapy for relieving pain in patients with spinal metastases from lung adenocarcinoma: analysis of clinical efficacy[J]. Journal of Interventional Radiology, 2025, 34(8): 851-855. DOI: 10.3969/j.issn.1008-794X.2025.08.009.
[23]Sesqué A, Dang NP, Coste A, et al. Orbitofrontal reconstruction with a three-dimensional titanium patient-specific implant after intraosseous haemangioma resection[J]. J Craniofac Surg, 2021, 32(1):69-72. DOI:10.1097/SCS.0000000000006935.
[24]Zhang K, Qu J, Deng S, et al. Serum IL-24 combined with CA125 as screening and prognostic biomarkers for NSCLC[J]. Cell Biol Int, 2024, 48(8): 1160-1168. DOI: 10.1002/cbin.12173.
[25]Jiang M, Chen P, Guo X, et al. Identification of EGFR mutation status in male patients with non-small-cell lung cancer: role of 18F-FDG PET/CT and serum tumor markers CYFRA21-1 and SCC-Ag[J]. EJNMMI Res, 2023, 13(1): 27. DOI: 10.1186/s13550-023-00976-5.
[26]Yao XS, Yan D, Jiang XX, et al. Short-term outcomes of radiofrequency ablation for hepatocellular carcinoma using cone-beam computed tomography for planning and image guidance[J]. World J Clin Cases, 2021, 9(7): 1580-1591. DOI: 10.12998/wjcc.v9.i7.1580.
[27]Olszyna-Serementa M, Zaborowska-Szmit M, Szmit S, et al. Performance-status deterioration during sequential chemo-radiotherapy as a predictive factor in locally advanced non-small cell lung cancer[J]. Curr Oncol, 2023, 30(2): 2049-2060. DOI: 10.3390/curroncol30020159.
[28]Jiang L, Li K, Lu S, et al. Mapping the EORTC QLQ-C30 and QLQ-LC13 to the SF-6D utility index in patients with lung cancer using machine learning and traditional regression methods[J]. Health Qual Life Outcomes, 2025, 23(1): 66. DOI: 10.1186/s12955-025-02394-8.