Experimental study on enhancing the quality of ex vivo placental tissue computed tomography angiography imaging using a self-setting barium sulfate composite material casting technology

Expand
  • 1. Department of Ultrasound Medicine, Xiangyang Central Hospital, Xiangyang 441000, Hubei Province, China; 2. Xiangyang Maternal and Child Health Hospital, Xiangyang 441000, Hubei Province, China; 3. Changsha Medical University, Changsha 410219, Hunan Province, China; 4. Department of Anatomy, Southern Medical University, Guangzhou 510515, Guangdong Province, China; 5. Department of Ultrasound, the Second Affiliated Hospital of Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China

Received date: 2024-11-29

  Online published: 2025-10-18

Abstract

Objective    To optimize the imaging of computed tomography angiography (CTA) of ex vivo placental tissue by using a self-curing barium sulfate composite material for arteriovenous casting. Methods   Normal full-term placentas were selected and randomly divided into two groups. Each group underwent CT scanning and 3D reconstruction using either traditional contrast agents or the self-curing barium sulfate composite material.   Results   The self-curing barium sulfate composite significantly enhanced the vascular filling and branch clarity in the CTA images. Blinded visual scoring demonstrated that the quality of CTA images obtained with the casting method surpassed those obtained with traditional methods, validating its effectiveness in ex vivo placental vascular studies.   Conclusions    The self-curing barium sulfate composite material shows significant advantages in ex vivo placental vascular research, improving the accuracy of placental pathology studies and clinical diagnoses. It provides new methodologies for diagnosing and treating related diseases.

Cite this article

Feng Ruizhi , Hu yang, Chen Yuhua, Lv Yang, Wu You, Dai Jingxing, Wu Zhixin, Wang Yu . Experimental study on enhancing the quality of ex vivo placental tissue computed tomography angiography imaging using a self-setting barium sulfate composite material casting technology[J]. Chinese Journal of Clinical Anatomy, 2025 , 43(5) : 618 -621 . DOI: 10.13418/j.issn.1001-165x.2025.5.19

References

[1]  Turco MY, Gardner L, Kay RG, et al. Trophoblast organoids as a model for maternal-fetal interactions during human placentation[J]. Nature, 2018, 564(7735): 263-267. DOI: 10.1038/s41586-018-0753-3.
[2] Hitzerd E, Reijnders IF, Mulders A, et al. Larger first-trimester placental volumetric parameters are associated with lower pressure and more flow-mediated vasodilation of the fetoplacental vasculature after delivery[J]. Front Physiol,2020,11:6. DOI: 10.3389/fphys. 2020. 00006.
[3]  Moran CM, Thomson AJW. Preclinical ultrasound imaging-a review of techniques and imaging applications[J]. Front Phys, 2020, 8: 124. DOI: 10.3389/fphy.2020.00124.
[4] Melbourne A, Schabel MC, David AL, et al. Magnetic resonance imaging of placental Intralobule structure and function in a pre-clinical nonhuman primate model[J]. Biol Reprod, 2024, 110(6): 1065-1076. DOI: 10.1093/biolre/ioae035.
[5] Link D, Many A, Ben Sira L, et al. Placental vascular tree characterization based on ex-vivo MRI with a potential application for placental insufficiency assessment[J]. Placenta, 2020, 101: 252-260. DOI: 10.1016/j.placenta.2020.05.001.
[6]  Lê MP, Pencolé L, Peytavin G, et al. Placental transfer of doravirine, a recent HIV-1 NNRTI in the ex vivo human cotyledon perfusion model[J]. J Antimicrob Chemother, 2021, 76(9): 2364-2367. DOI: 10.1093/jac/dkab202.
[7] Collet C, Chevalier B, Cequier A, et al. Diagnostic accuracy of coronary ct angiography for the evaluation of bioresorbable vascular scaffolds[J]. JACC Cardiovasc Imaging, 2018, 11(5): 722-732. DOI: 10.1016/j.jcmg.2017.04.013.
[8] Pearce SC, Coia HG, Karl JP, et al. Intestinal in vitro and ex vivo models to study host-microbiome interactions and acute stressors[J]. Front Physiol, 2018, 9: 1584. DOI: 10.3389/fphys.2018.01584.
[9]  张家栋, 李长征, 陈跃, 等. 改良自凝牙托材料在胎盘血管铸型中的应用[J]. 福建中医学院学报, 2003, 13(2): 33. DOI: 10.3969/j.issn.1004-5627.2003.02.017.
       Zhang JD, Li CZ, Chen Y, et al. Improved Self-Curing Dental Baseplate Material in Placental Vascular Casting Application. Journal of Fujian College of TCM, 2003, 13(2): 33. DOI: 10.3969/j.issn.1004-5627.2003.02.017.
[10]Walter A, Paul-Gilloteaux P, Plochberger B, et al. Correlated multimodal imaging in life sciences: expanding the biomedical horizon[J]. Front Phys, 2020, 8: 47. DOI: 10.3389/fphy.2020.00047.
[11]Ahmed A, Hamza HM. Barium sulfate absorption and sensitivity[J]. Radiology, 1989, 172(1): 213-214. DOI: 10.1148/radiology.172.1.213-b.
[12]Xu Y, Huettig F, Schille C, et al. Peel bond strength between 3D printing tray materials and elastomeric impression/adhesive systems: a laboratory study[J]. Dent Mater, 2020, 36(7): e241-e254. DOI: 10.1016/j.dental.2020.04.015.
[13]Elbæk Madsen K, Mariager C, Duvald CS, et al. Ex vivo human placenta perfusion, metabolic and functional imaging for obstetric research-a feasibility study[J]. Tomography, 2019, 5(4): 333-338. DOI: 10.18383/j.tom.2019.00016.
Outlines

/