目的　探索食蟹猴子宫内膜异位症（简称内异症）病证结合模型构建的方法。  方法　（1）6只雌性食蟹猴随机分为实验组5只、对照组1只，实验组开腹行宫颈环扎术，对照组仅开腹。（2）于术前、术中及术后第1、2、3个月运用PSI测量猴舌血液灌注量。（3）术后3个月腹腔镜探查，因均未见内异症病灶，改进建模方法：将猴分为实验组4只、对照组2只，实验组月经期收集子宫内膜组织盆腔内注射，连续使用3个月免疫抑制剂，对照组不作处理。  结果　（1）宫颈环扎后3个月后腹腔镜探查，两组均未见内异症病灶。（2）猴子术后2月舌部血液灌注量明显高于对照组，差异有统计学意义（P<0.05）。（3）每只猴的舌面及舌底血液灌注量变化趋势一致。（4）改进建模方案后3个月腹腔镜探查示，实验组重度盆腔粘连、子宫表面血管增生并充血明显，一只猴可见内异症病灶，对照组则无。  结论　收集子宫内膜盆腔内注射、加用免疫抑制剂可以构建食蟹猴内异症模型。运用PSI测量猴舌部血液灌注量的方法稳定可行，有望成为疾病病证结合模型舌象的量化评价方法。

Objective　To explore the method of constructing the primate model combined with disease of endometriosis and syndrome.　Methods　(1) Six female cynomolgus monkeys were randomly divided into a modeling group (n=5) and a control group (n=1). The modeling group was treated with transabdomal cervical cerclage while the control group was only observed through an open surgery. (2) The blood perfusion of the tongue was measured by PeriCam PSI perfusion speckle imager before the first modeling operation, at the modeling month and after the first, second and third months of modeling. (3) Laparoscopic exploration was performed three months after  the operation. Since no endometriosis lesions were found in the pelvis of the monkey, we changed the modeling method: the monkeys were re-assigned into the modeling group (n=4) and the control group(n=2). In the modeling group, the endometrial tissue fragments were collected during the menstrual period and intraperitoneal injection, and immunosuppressive agents were administered for three months.　Results:　(1) In the laparoscopy after three months of cervical cerclage, no endometriosis lesion was seen in the two groups. (2) The blood perfusion in the monkeys was significantly higher in the modeling group than that in the control group at 2 months after the operation (P<0.05).(3) The trend of blood perfusion  in the surface and base of the tongue of each monkey was consistent.(4) Three months after the intraperitoneal injection with the immunosuppressive agents, the modeling group had severe pelvic adhesions, vascular hyperplasia and hyperemia on the serosa of the uterine under the laparoscopy. The endometriosis lesions were found in one of the modeling monkeys.  Conclusion  The endometrial pelvic injection with the administration of the immunosuppressive agents is a feasible approach for constructing primate endometriosis models. The method of measuring the blood perfusion of the tongue of the cynomolgus monkey using PSI is easy and stable, and it may become a quantitative evaluation method for the tongue image of the disease syndrome combination model.