慢性踝关节不稳发病机制研究进展

陈立煜, 张秀瑞, 肖进

中国临床解剖学杂志 ›› 2026, Vol. 44 ›› Issue (2) : 239-241.

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中国临床解剖学杂志 ›› 2026, Vol. 44 ›› Issue (2) : 239-241. DOI: 10.13418/j.issn.1001-165x.2026.2.18
综述

慢性踝关节不稳发病机制研究进展

  • 陈立煜1,2#,    张秀瑞2#,    肖进1,2*
作者信息 +

Research progress on the pathogenesis of chronic ankle instability 

  • Chen Liyu1,2# , Zhang Xiurui2#, Xiao Jin1,2*
Author information +
文章历史 +

摘要

慢性踝关节不稳(Chronic ankle instability, CAI)是一种由急性踝关节扭伤引发的复杂病理状态,表现为反复的关节不稳、功能障碍及活动受限。虽然CAI的临床表现已经得到广泛认识,但其具体的发病机制尚未完全明确。本文系统回顾了CAI的发病机制,重点分析了解剖学基础、韧带损伤导致的原发性损伤,病理机械性改变、感觉-知觉障碍以及运动行为障碍等,并比较了传统分类方法与新兴多维模型的特点,提出综合不稳理论对临床评估的重要性。为未来研究和临床实践提供了一定的启发。

Abstract

Chronic Ankle Instability (CAI) is a complex pathological condition triggered by acute ankle sprains, characterized by recurrent joint instability, functional impairments, and activity limitation. Although the clinical manifestations of CAI are widely acknowledged, its specific pathogenesis have not been fully clarified. This review systematically examines the pathogenesis of CAI, with a particular emphasis on its anatomical foundations, primary injuries due to ligamentous injury, pathomechanical impairments, sensory-perceptual impairments s, motor- behavioral impairments,. Additionally, it contrasts traditional classification approaches with emerging multidimensional models, highlighting the clinical significance of the comprehensive instability theory in assessment. This review offers valuable insights for advancing future research and optimizing clinical practice.

关键词

慢性踝关节不稳 /   /   / 踝关节扭伤 /   /   / 距腓前韧带 /   /   / 发病机制 /   /   / 病理机械性改变 /   /   / 感觉-知觉障碍 /   /   / 运动行为障碍 /   /   / 神经生理适应性改变

Key words

Chronic ankle instability /   /   / Ankle sprains /   /   / Anterior talofibular ligament /   /   / Pathogenesis / Pathomechanical impairments /   / Sensory-perceptual impairments / Motor-behavioral impairments / Neurophysiological adaptations

引用本文

导出引用
陈立煜, 张秀瑞, 肖进. 慢性踝关节不稳发病机制研究进展[J]. 中国临床解剖学杂志. 2026, 44(2): 239-241 https://doi.org/10.13418/j.issn.1001-165x.2026.2.18
Chen Liyu , Zhang Xiurui, Xiao Jin. Research progress on the pathogenesis of chronic ankle instability [J]. Chinese Journal of Clinical Anatomy. 2026, 44(2): 239-241 https://doi.org/10.13418/j.issn.1001-165x.2026.2.18
中图分类号: R658.3         

参考文献

[1]Chang SH, Morris BL, Saengsin J,et al. Diagnosis and treatment of chronic lateral ankle instability: review of our biomechanical evidence[J]. J Am Acad Orthop Surg, 2021, 29(1):3-16. DOI: 10.5435/JAAOS-D-20-00145. PMID: 33347006. 
[2] Golanó P, Vega J, de Leeuw PA, et al. Anatomy of the ankle ligaments: a pictorial essay[J]. Knee Surg Sports Traumatol Arthrosc, 2010, 18(5):557-569. DOI: 10.1007/s00167-010-1100-x. 
[3]Hubbard TJ. Ligament laxity following inversion injury with and without chronic ankle instability[J]. Foot Ankle Int, 2008, 29(3):305-311. DOI: 10.3113/FAI.2008.0305.
[4]Dhillon MS, Patel S, Baburaj V. Ankle sprain and chronic lateral ankle instability: optimizing conservative treatment.[J] Foot Ankle Clin, 2023, 28(2):297-307. DOI: 10.1016/j.fcl.2022.12.006. Epub 2023 Feb 26. PMID: 37137624.
[5]Jung HG, Kim NR, Kim TH, et al. Magnetic resonance imaging and stress radiography in chronic lateral ankle instability[J]. Foot Ankle Int, 2017, 38(6):621-626. DOI: 10.1177/1071100717693207. 
[6]Carbone A, Rodeo S. Review of current understanding of post-traumatic osteoarthritis resulting from sports injuries[J]. J Orthop Res, 2017, 35(3):397-405. DOI: 10.1002/jor.23341. 
[7]Liu K, Gustavsen G, Royer T, et al. Increased ligament thickness in previously sprained ankles as measured by musculoskeletal ultrasound[J]. J Athl Train, 2015, 50(2):193-8. DOI: 10.4085/1062-6050-49.3.77.
[8]Feger MA, Snell S, Handsfield GG, et al. Diminished foot and ankle muscle volumes in young adults with chronic ankle instability[J]. Orthop J Sports Med, 2016, 4(6):2325967116653719. DOI: 10.1177/2325967116653719. 
[9]Munn J, Sullivan SJ, Schneiders AG. Evidence of sensorimotor deficits in functional ankle instability: a systematic review with meta-analysis[J]. J Sci Med Sport, 2010, 13(1):2-12. DOI:10.1016/j.jsams. 2009.03.004. 
[10]Riemann BL, Myers JB, Stone DA, et al. Effect of lateral ankle ligament anesthesia on single-leg stance stability[J]. Med Sci Sports Exerc, 2004, 36(3): 388-396. DOI:10.1249/01.mss.0000117131.93989.9b.
[11]Nanbancha A, Tretriluxana J, Limroongreungrat W, et al. Decreased supraspinal control and neuromuscular function controlling the ankle joint in athletes with chronic ankle instability[J]. Eur J Appl Physiol, 2019, 119(9):2041-2052. DOI: 10.1007/s00421-019-04191-w. 
[12]Kim KM, Ingersoll CD, Hertel J. Altered postural modulation of Hoffmann reflex in the soleus and fibularis longus associated with chronic ankle instability[J]. J Electromyogr Kinesiol, 2012, 22(6):997-1002. DOI: 10.1016/j.jelekin.2012.06.002.
[13]Feger MA, Donovan L, Hart JM, et al. Lower extremity muscle activation in patients with or without chronic ankle instability during walking[J]. J Athl Train, 2015, 50(4):350-357. DOI: 10.4085/1062-6050-50.2.06.
[14]Kim JS, Kim KM, Chang E, et al. Spinal reflex excitability of lower leg muscles following acute lateral ankle sprain: bilateral inhibition of soleus spinal reflex excitability[J]. Healthcare (Basel), 2022, 10(7):1171. DOI: 10.3390/healthcare10071171. 
[15]Kim KM, Kim JS, Needle AR. Soleus arthrogenic muscle inhibition following acute lateral ankle sprain correlates with symptoms and ankle disability but not with postural control[J]. J Sport Health Sci, 2024, 13(4):559-568. DOI: 10.1016/j.jshs.2024.02.005. 
[16]Song K, Kang TK, Wikstrom EA, et al. Effects of reduced plantar cutaneous sensation on static postural control in individuals with and without chronic ankle instability[J]. J Sci Med Sport, 2017, 20(10):910-914. DOI: 10.1016/j.jsams.2016.04.011. 
[17]Hoch MC, McKeon PO. Peroneal reaction time after ankle sprain: a systematic review and meta-analysis[J]. Med Sci Sports Exerc, 2014, 46(3):546-56. DOI: 10.1249/MSS.0b013e3182a6a93b. 
[18] Lepley AS, Lepley LK. Mechanisms of arthrogenic muscle inhibition[J]. J Sport Rehabil, 2022, 31:707-716. DOI: 10.1123/jsr.2020-0479.
[19]Terada M, Kosik KB, McCann RS, et al. Diaphragm contractility in individuals with chronic ankle instability[J]. Med Sci Sports Exerc, 2016, 48(10):2040-2045. DOI: 10.1249/MSS.0000000000000994. 
[20]Kosik KB, Terada M, Drinkard CP, et al. Potential corticomotor plasticity in those with and without chronic ankle instability[J]. Med Sci Sports Exerc,2017, 49(1):141-149. DOI: 10.1249/MSS.00000000 00001066. 
[21]Cho BK, Park JK, Choi SM, et al. The peroneal strength deficits in patients with chronic ankle instability compared to ankle sprain copers and normal individuals[J]. Foot Ankle Surg, 2019, 25(2):231-236. DOI: 10.1016/j.fas.2017.10.017 . 
[22]Cho BK, Park JK, Choi SM, et al. The peroneal strength deficits in patients with chronic ankle instability compared to ankle sprain copers and normal individuals[J]. Foot Ankle Surg, 2019, 25(2):231-236. DOI: 10.1016/j.fas.2017.10.017.

[23] Hertel J, Corbett RO. An updated model of chronic ankle instability[J]. J Athl Train, 2019, 54(6):572-588. DOI: 10.4085/1062-6050-344-18.

[24]Yu ZP. Correlation of anxiety and depression with ankle function in chronic ankle instability patients and analysis of risk factors[J]. World J Psychiatry, 2025, 15(7):103185. DOI: 10.5498/wjp.v15.i7.103185. 
[25] Suttmiller AMB, Cavallario JM, Baez SE, et al. Perceived instability, pain, and psychological factors for prediction of function and disability in individuals with chronic ankle instability[J]. J Athl Train, 2022, 57(11-12):1048-1054. DOI: 10.4085/1062-6050-0605.21. 
[26]Maricot A, Dick E, Walravens A, et al. Brain neuroplasticity related to lateral ankle ligamentous injuries: a systematic review[J]. Sports Med, 2023, 53(7):1423-1443. DOI: 10.1007/s40279-023-01834-z. 
[27]Hwang UJ, Kwon OY, Kim JH, et al. Machine learning for classifying chronic ankle instability based on ankle strength, range of motion, postural control and anatomical deformities in delivery service workers with a history of lateral ankle sprains[J]. Musculoskelet Sci Pract, 2025, 75:103230. DOI: 10.1016/j.msksp.2024.103230. 
[28]Hwang UJ, Kwon OY, Kim JH, et al. Classification of chronic ankle instability using machine learning technique based on ankle kinematics during heel rise in delivery workers[J]. Digit Health, 2024, 10:20552076241235116. DOI: 10.1177/20552076241235116. 
[29]O'Driscoll J, Delahunt E. Neuromuscular training to enhance sensorimotor and functional deficits in subjects with chronic ankle instability: A systematic review and best evidence synthesis[J]. Sports Med Arthrosc Rehabil Ther Technol, 2011, 3:19. DOI: 10.1186/1758-2555-3-19. 
[30] Forsyth L, Bonacci J, Childs C. A pilot randomised control trial of the efficacy of stability-based training with visualisation for people with chronic ankle instability[J]. Med Biol Eng Comput, 2022, 60(4):1199-1209. DOI: 10.1007/s11517-022-02533-z.

基金

国家自然科学基金(82302723);广东省自然科学基金面上项目(2023A1515010918);茂名市电白区人民医院科研启动专项(MDH2025BSOS001)

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