三维重建技术辅助REA术治疗NSLCL患者的临床疗效及并发症观察

doi:10.13418/j.issn.1001-165x.2026.2.11

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中国临床解剖学杂志 ›› 2026, Vol. 44 ›› Issue (2) : 194-200. DOI: 10.13418/j.issn.1001-165x.2026.2.11

临床研究

三维重建技术辅助REA术治疗NSLCL患者的临床疗效及并发症观察

杨斌，赵海龙，郑凤长，魏征，孙朋，郭涛，杨伟林*

作者信息 +

Clinical efficacy and complications of three-dimensional reconstruction technique-assisted REA in the treatment of NSLCL patients

Yang Bin, Zhao Hailong, Zheng Fengchang, Wei Zheng, Sun Peng, Guo Tao, Yang Weilin*

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文章历史 +

摘要

目的探讨三维重建技术辅助肺部肿瘤射频消融（REA）术治疗椎体侵袭性非小细胞肺癌（NSLCL）患者的临床疗效及安全性。方法 110例NSLCL患者根据治疗方案不同分为三维重建规划组51例（采用三维重建技术辅助REA术治疗）和二维CT规划组59例（采用二维CT规划进针路径辅助REA术治疗）。比较两组患者的手术相关指标、疼痛视觉模拟量表（VAS）评分、肿瘤标志物、功能恢复情况、生存质量、术后3个月的肿瘤消融靶区体积以及手术相关并发症的发生率。结果与二维CT规划组相比，三维重建规划组CT扫描次数、术中出血量较少，进针时间、手术时间和术后住院时间均较短（P<0.05）；术后6 h、24 h，三维重建规划组VAS评分低于二维CT规划组（P<0.05）；术后1个月、3个月，三维重建规划组血清糖类抗原125（CA125）、癌胚抗原（CEA）、鳞状细胞癌抗原（SCC-Ag）水平均低于二维CT规划组（P<0.05），Karnofsky功能状态（KPS）评分和欧洲癌症研究与治疗组织生命质量测定量表（EORTC QLQ-C30）评分优于二维CT规划组（P<0.05）；术后3个月，三维重建规划组肿瘤消融靶区体积小于二维CT规划组（P<0.05）；三维重建规划组并发症发生率低于二维CT规划组（P<0.05）。结论三维重建技术辅助REA术治疗NSLCL可有效控制肿瘤进展，促进患者术后恢复，改善其生存质量，并降低并发症风险，具有重要的临床应用价值。

Abstract

Objective To investigate the clinical efficacy and safety of three-dimensional reconstruction technique-assisted radiofrequency ablation (REA) of lung tumors in the treatment of patients with non-small cell lung cancer with with spinal invasion (NSLCL). Methods A total of 110 patients with NSLCL were divided into a three-dimensional reconstruction planning group (51 cases, three-dimensional reconstruction technique-assisted REA) and a two-dimensional CT planning group (59 cases, two-dimensional CT planning-assisted REA) based on different treatment regimens. The surgery-related indicators, pain visual analogue scale (VAS) score, tumor markers, functional recovery, quality of life, tumor ablation target volume at 3 months after surgery and incidence rates of surgery-related complications were compared between the two groups. Results Compared with two-dimensional CT planning group, the CT scan frequency and intraoperative blood loss volume in three-dimensional reconstruction planning group were less, and the needle insertion time, surgical time and postoperative hospital stay were shorter (P<0.05). The VAS scores in three-dimensional reconstruction planning group at 6 and 24 hours after surgery were lower than those in two-dimensional CT planning group (P<0.05). At 1 month and 3 months after surgery, the levels of serum carbohydrate antigen 125 (CA125), carcinoembryonic antigen (CEA) and squamous cell carcinoma antigen (SCC-Ag) in three-dimensional reconstruction planning group were lower than those in two-dimensional CT planning group (P<0.05), and the Karnofsky performance status (KPS) score and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 (EORTC QLQ-C30) score were better compared with two-dimensional CT planning group (P<0.05). At 3 months after surgery, the tumor ablation target volume in three-dimensional reconstruction planning group was smaller than that in two-dimensional CT planning group (P<0.05). The incidence rates of complications were significantly lower in three-dimensional reconstruction planning group than those in two-dimensional CT planning group (P<0.05). Conclusions Three-dimensional reconstruction technique-assisted REA in the treatment of NSLCL can effectively control tumor progression, promote postoperative recovery, improve the quality of life and reduce the risk of complications, with important clinical application value.

导出引用

杨斌, 赵海龙, 郑凤长, 魏征, 孙朋, 郭涛杨伟林. 三维重建技术辅助REA术治疗NSLCL患者的临床疗效及并发症观察[J]. 中国临床解剖学杂志. 2026, 44(2): 194-200 https://doi.org/10.13418/j.issn.1001-165x.2026.2.11

Yang Bin, Zhao Hailong, Zheng Fengchang, Wei Zheng, Sun Peng, Guo Tao, Yang Weilin. Clinical efficacy and complications of three-dimensional reconstruction technique-assisted REA in the treatment of NSLCL patients[J]. Chinese Journal of Clinical Anatomy. 2026, 44(2): 194-200 https://doi.org/10.13418/j.issn.1001-165x.2026.2.11

中图分类号： R734.2 R322.35

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