Chinese Journal of Clinical Anatomy >
The clinical study of bone biopsy and bone microstructure of elderly intertrochanteric fractures
Received date: 2014-07-18
Online published: 2015-04-21
Objective To obtain the reference value of the bone micrstructrual morphology for therapeutic guidance by investigation of bone microstructure in bone biopsy from intertroachteric fractures in elderly patients. Methods The experimental group: 15 female patients and 15 male patients were who have femoral intertrochanteric fracture caused by low or moderate energy trauma and need of surgical treatment were included. Control group: 24 fresh cadaveric femoral specimens, 12 from male and 12 from female, were included. A Trephine with a diameter of 1 cm was used to obtain a bone column with a size being 2cm in height and 1cm in diameter (the drill was placed on the intertrochanteric region by a uniform approach). The bone column was used for microstructural morphological study and quantitative analysis. Results The trabecular connectivity decreased and the trabecula gradually disappeared. in a certain width of bone, the trabecula was sparse and the percentage of trabecular area versus the whole bone area was relatively small. The average distance between trabeculae was long and the number of trabecularnodes was relatively small, while the free ends of the bone trabeculae increased. Comparison of Trabecular number, Trabecular width, Trabecular separation, %Trabecular bone area, Number of nodes/Free end between the two groups revealed significantly statistical difference(P<0.05). Conclusions The elderly femoral intertrochanteric bone microstructure morphologic parameters have important guiding significances to osteoporosis treatment and appropriate functional exercise.
LI Jian-Chi , LIANG Jiang-Qing , LI Kang , CHEN Hui-Beng , CA Ti-Bei , XU Zi-Jiang , TAN Jia-Qun , XIE Wei-Jian . The clinical study of bone biopsy and bone microstructure of elderly intertrochanteric fractures[J]. Chinese Journal of Clinical Anatomy, 2015 , 33(2) : 226 -228 . DOI: 10.13418/j.issn.1001-165x.2015
[1] Nishizawa Y, Ohta H, Miura M, et al. Guidelines for the use of bone metabolic markers in the diagnosis and treatment of osteoporosis
[J]. J Bone Miner Metab, 2013, 31(1):1-15.
[2] Dempster DW, Ferguson-Pell MW, Mellish RW, et al. Relationships between bone structure in the iliac crest and bone structure and strength in the lumbar spine
[J]. Osteoporos Int, 1993, 3(2):90-96.
[3] 李建赤，徐自强，黄必留，等. 老年性髋部骨折骨密度与骨形态计量学的关系
[J]. 中国骨质疏松杂志，2011, 17(11):977-980.
[4] 林华，徐天舒，范璐，等. 5mg唑来膦酸治疗绝经后骨质疏松及其骨折
[J]. 中华创伤骨科杂志，2012, 18(1):734-737.
[5] Cauley JA，Black D，Boonen S，et a1．Once-yearly zoledronic acid and days of disability，bed rest and back pain：randomised controlled HORIZON Pivotal Fracture Trial
[J]．J Bone Miner Res，2011，26(5):984-992．
[6] Recker RR, Ste-Marie LG, Langdahl B, et al. Effects of intermittent intravenous ibandronate injections on bone quality and micro-architecture in women with postmenopausal osteoporosis: The DIVA study
[J]. Bone, 2010, 46(3):660-665.
[7] Ma YL, Zeng QQ, Chiang AY, et al. Effects of teriparatide on cortical histomorphometric variables in postmenopausal women with or without prior alendronate treatment
[J]. Bone. 2014, 59:139-147.
[8] 许碧莲，徐道华，陈文双，等. 小檗碱对糖皮质激素性骨质疏松大鼠松质骨和皮质骨的影响
[J]. 中国药理学通报，2011, 27(7):965-970.
[9] 于琼，吴铁，崔燎. 阿司匹林对环磷酰胺大鼠皮质骨的影响
[J]. 中国药理学通报，2011, 27(2):221-225.
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