Chinese Journal of Clinical Anatomy >
The experimental research of allogeneic bone and periosteum for the treatment of New Zealand white rabbit bone defects
Received date: 2013-10-10
Online published: 2014-06-04
Objective To investigate the feasibility and repair mechanism of periosteum and allogeneic bone for treatment of bone defects in the New Zealand white rabbits. Methods 48 New Zealand white rabbits were randomly divided into 3 groups, namely, the experimental group, control group and blank group. The effect and mechanism of periosteum and allogeneic bone harvested for treatment of bone defects was determined by X-ray, real time fluorescent quantitative PCR and HE staining. Results The bone defects of the experimental group and control group healed while the bone defects of the blank group did not heal as shown by the examination of X-ray. The new bone trabecular arrangement was good in the experimental group and there was still a small amount of residual bone allograft according to HE staining. The new bone trabecular arrangement was good in the control group too. The blank group could not see clear bone trabeculae. The Spp-1 and BMP-2 gene expression of the experimental group was higher than that of the control group (P<0.05). The ColⅠα1 gene expression of the experimental group was lower than that of the control group (P<0.05). Conclusion Periosteum and allogeneic bone could effectively promote the healing of bone defects.
Key words： Periosteum; Allogeneic bone; Bone defects; New Zealand white rabbit
BI Zhi-Wei , HUANG Dong , ZHANG Da-Wei , NIU Guo-Qiang , OU Yang-Hai-Xiang , LI Yu-Meng . The experimental research of allogeneic bone and periosteum for the treatment of New Zealand white rabbit bone defects[J]. Chinese Journal of Clinical Anatomy, 2014 , 32(3) : 335 -339 . DOI: 10.13418/j.issn.1001-165x.201
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