Chinese Journal of Clinical Anatomy >
Changes of MCT2 expression in cerebral cortex after formalin-induced rat pain model
Received date: 2013-11-25
Online published: 2014-06-04
Objective To investigate the changeofmonocarboxylate transporters 2( MCT2) expression in cerebral cortex primary somatosensory cortex hindlimb region（S1HL）under the condition of pain stimulation, so as to explore the involvement of MCT2 in the pain adjustment mechanism in a rat pain model. Methods Immunohistochemical staining(IHC), Western blot and Computing-image analysis system were used to detect the changes of MCT2 expression in the cerebral cortex S1HL of the formalin-induced rat pain model. Results Compared with the control group, the number and IOD of MCT2-positive neurons in the cerebral cortex S1HL of formalin-treated rats began to increase at 1h，reaching the highest level on 3d and declined on 7d ,but still higher than those in the control group (P<0.05).The Western blot showed that the alteration tendency of MCT2 expression was consistent with those of the number and IOD of MCT2-positive neurons. Conclusion Our results indicated that MCT2 is up-regulated under the condition of pain stimulation, which might be involved in the formalin-induced pain and behavior regulation.
Key words： Rat pain model; MCT2; S1HL
SONG Kai-Qin , KANG Cheng-Qiao , SUN Shan-Quan , HUANG Juan , XU Jin , LI Wen-Juan , JIANG Jin . Changes of MCT2 expression in cerebral cortex after formalin-induced rat pain model[J]. Chinese Journal of Clinical Anatomy, 2014 , 32(3) : 312 -315 . DOI: 10.13418/j.issn.1001-165x.2014
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