Chinese Journal of Clinical Anatomy >
Revascularization study of the hollow hydroxyapatite composite rhBMP-2 in repairing the bone defect
Received date: 2013-10-28
Online published: 2014-04-21
Objective To study and observe the revascularization process of the hollow hydroxyapatite composite rhBMP-2 in repairing the bone defect. Methods 48 adult male New Zealand rabbits with artificially-established radius defect were randomly divided into 3 groups, each group were implanted with the following materials: hollow HA/ rhBMP-2 composite artificial bone(A groups), hollow HA(B groups),rhBMP-2(C groups). After implantation in 4、8、12、16 weeks, the process was observed using radionuclide bone imaging, X ray, histological observation. Results Different time after the operation, X-ray and histological score, bone radionuclide-gathering strength of the rabbits in the hollow HA/ rhBMP-2 composite artificial bone group in the were higher than that of hollow HA artificial bone (P＜0.05). In the control group, synostosis and bone sclerosis were observed in bone defect area bone defect failed to heal. Conclusion Hollow HA/ rhBMP-2 composite artificial bone has good ability in revascularization and repairing segmental bone defect and is expected to be an ideal material for bone defect repair.
LUO Feng-Gang , XIONG Long , CENG Jian-Hua , XIONG Gao , TUN Ceng-Zhi , LING Hua-Jun , JIA Xiong-Chao . Revascularization study of the hollow hydroxyapatite composite rhBMP-2 in repairing the bone defect[J]. Chinese Journal of Clinical Anatomy, 2014 , 32(2) : 196 -200 . DOI: 10.13418/j.issn.1001-165x.2014
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