Objective   To explore the clinical effect of individualized "three-set" guide assisted endoscopic lumbar  discectomy in the treatment of lumbar disc herniation.    Methods    According to the inclusion and exclusion criteria, 16 patients with lumbar disc herniation from December to November were selected and randomly divided into two groups. The control group (n=8) was treated with traditional methods. The experimental group (n=8) was assisted by the individualized "three-set" guide in intervertebral foramen surgery. The CT data of patients were collected and imported into the software before operation to conduct individualized design, simulate the surgical puncture path, and determine the needle insertion position, needle insertion angle and needle insertion depth (referred to as "three-set"). The individualized "three-set" guider was placed on the body surface, and the puncture angle and direction were adjusted according to the correction value, and the accurate puncture was realized by the guider. The times of fluoroscopy, puncture timing and puncture frequency of the two groups were recorded and statistically analyzed.  Results  The times of fluoroscopy, puncture timing and puncture frequency of the experimental group were less than those of the control group, with statistical significance (P<0.01,P<0.01,P<0.05).    Conclusions    It is feasible and effective to use the individualized "three-set" guide to assist intervertebral foramen surgery in the treatment of lumbar disc herniation.