Objective To evaluate etanercept and conventional synthetic disease modifying anti-rheumatic drugs (csDMARDs) in treating ankylosing spondylitis (AS) and its mid-term therapeutic effect among mild-to-moderate AS patients. Methods Sixty-four patients diagnosed with mild-to-moderate AS treating in our department from 2017 to 2018 were enrolled. Etanercept was used in the short term during the active stage of the disease, and csDMARDs combination was used for oral administration during the remission stage. Clinical remission rate was assessed before treatment, 3, 6 and 12 months after treatment. Tthe therapeutic effect was evaluated by BASFI, BASDAI and SQOL-AS scales. Results Patients Global, BASFI, BASDAI and ASDAS-CRP scores, CRP and ESR values decreased (P<0.05), while SQOL-AS scores increased (P<0.05) at 3, 6 and 12 months of follow-up. At the end of the follow-up, 85.9% and 79.7% of all enrolled patients achieved ASAS 20, ASAS 40 remission criteria, respectively. No tuberculosis, opportunistic infection or tumor occurred during the treatment. Conclusions For mild to moderate AS, the sequential combination of etanercept and csDMARDs shows satisfied mid-term therapeutic efficacy and expects to be an alternative treatment for those low-income AS patients.
Jiang Weizhou, Hu Yong, Song Minkai, Liu Huan, Huang Wenhua, Xiao Jun
. Sequential application of etanercept and csDMARDs in treating ankylosing spondylitis: A prospectively mid-term follow-up study[J]. Chinese Journal of Clinical Anatomy, 2023
, 41(1)
: 97
-104
.
DOI: 10.13418/j.issn.1001-165x.2023.1.18
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