Objective To compare the pregnancy outcomes of intra-uterine insemination (IUI) in natural cycles and ovulation cycles of advanced age women and analyze the influencing factors. Methods The clinical data and pregnancy outcomes of 580 IUI cycles in advanced age women were retrospectively analyzed, including 201 natural cycles and 379 ovulation cycles. The mature follicle number, pregnancy rate, abortion rate were compared, and the effects of different ovulation induction protocols and different infertility causes were analyzed. Results There was no significant difference in the biochemical pregnancy rate (8.45% vs 11.60%), clinical pregnancy rate (7.46% vs 10.29%), and ectopic pregnancy rate (0% vs 2.56%) between the natural cycles and the ovulation cycles (P>0.05), but the abortion rate of natural cycles (8/15, 53.33%) was significantly higher than that of ovulation cycles (7/39, 17.95%) (P<0.05). In different ovulation induction protocols, the number of mature follicles of CC group (1.87±0.85), CC+HMG group ( 1.80±0.75) were significantly higher than those of LE group (1.29±0.53), LE+HMG group (1.38±0.63), HMG group (1.35±0.60) and rFSH group (1.35±0.48) (P<0.05). The clinical pregnancy rate of the CC group (1/23,4.35%) was significantly lower than that of the other groups (P<0.05). There was no significant difference in the abortion rate between those ovulation induction groups (P>0.05). There was no statistical difference in the clinical pregnancy rate between the natural cycles and the ovulation cycles (P>0.05). Conclusions The abortion rate of natural cycles of advanced age women is significantly higher than that of ovulation cycles. The appropriate methods of ovulation induction for advanced age women can improve the IUI live birth rate.
SUN Li, GE Ming-xiao, XING Wei-jie, CAI Liu-hong, TAO Xin, LI Xiao-li, OU Jian-ping
. Comparison and analysis of pregnancy outcome of intrauterine insemination in natural cycles and ovulation cycles of advanced age women[J]. Chinese Journal of Clinical Anatomy, 2020
, 38(3)
: 343
-347
.
DOI: 10.13418/j.issn.1001-165x.2020.03.020
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