The prevalence and related risk factors of hemorrhagic transformation in different subtype of cerebral infarction
GUO Wen-Chao, BO Su-Ti
Chinese Journal of Clinical Anatomy ›› 2013, Vol. 31 ›› Issue (4) : 480-483.
The prevalence and related risk factors of hemorrhagic transformation in different subtype of cerebral infarction
Objective To analyze the prevalence and related risk factors of hemorrhagic transformation (HT) in patients with different subtype of acute cerebral infarction. Methods The Clinical data of 977 patients with cerebral infarction were analyzed retrospectively. They were divided into HT group ( n=142) and non-HT group ( n=835) according to whether they had HT or not．TOAST classification in both groups was observed. The risk factors for HT were identified by univariate chi-square test and multivariate logistic regression analysis, and the incidences of HT in various types of cerebral infarction in the TOAST classification were compared． Results The results of multivariate logistic regression analysis showed that massive cerebral infarction (OR=10.498,95%CI 6.520～17.131,P=0.000), atrial fibrillation(OR=1.718, 95%CI 1.217～2.941, P=0.005), anticoagulation (OR=7.748, 95%CI 2.416～25.847, P=0.000), and diabetes (OR=1.817, 95%CI 1.135～2.903, P=0.012) were the independent risk factors for HT. Hypertension, high cholesterol, and the history of anti-platelet aggregation were not the independent risk factors for HT. In the TOAST classification, the HT incidence in patients with cardio embolic cerebral infarction was the highest (31.1%, 88/283), the HT incidence of small artery occlusion was lower (6.6%, 17/257), and the HT incidence of large artery atherosclerosis was (12.8%, 24/187). Conclusion Massive cerebral infarction, atrial fibrillation, anticoagulation, diabetes are the independent risk factors for HT. Cardioembolic cerebral infarction is one of the major reasons for the occurrence of HT．
Brain infarction / Risk factors / Hemorrhagic transformation
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