MRI study of deep cerebral veins after subarachniod hemorrhage in rabbits
DAI Zong-Fei, DENG Xue-Fei, ZHANG Zi-Han, SHU You-Zhi, ZHANG Yu, LI Da-Ku, JIA Xiang-Wei, MO Zi, HAN Hui
Chinese Journal of Clinical Anatomy ›› 2012, Vol. 30 ›› Issue (2) : 176-180.
MRI study of deep cerebral veins after subarachniod hemorrhage in rabbits
Objective To build a model of subarachnoid hemorrhage (SAH) in rabbit and observe the changes of diameters of the deep cerebral veins after SAH, in order to provide a new theoretical basis for the occurrence and therapy of vasospasm after SAH. Methods A total of 38 New Zealand rabbits were randomly divided into two groups: normal saline (NS) group (n=5), and SAH group (n=33). The SAH animals were made by infusing autologous arterial blood into the cisterna magna twice, and the NS group had saline instead of blood. The behavior and neurological function of animals in SAH group (4 rabbits) and in NS group (2 rabbits) were observed. Another 14 SAH rabbits were sacrificed and observed by microscopic anatomy. MR scan was performed 1 day before making model and 5 days after making model again in other rabbits. Results Microscopic anatomy showed that coagulated blood was obviously found around the ventral surface of brain stem, lateral ventricles and quadrigeminal cistern. In NS group, no statistical difference was found (P>0.05) among the diameters of internal cerebral vein (ICV), basilar vein (BV) and great cerebral vein (GV) before and after making model. In SAH group, the diameters of ICV, BV, GV were separately (0.57±0.13)mm, (0.38±0.08)mm, (1.33±0.31)mm before making model. However, the diameters of them were (0.42±0.08)mm, (0.25±0.12)mm, and (1.26±0.31)mm at 5 days after making model, which were significantly different compared to that at 0 day. Conclusions Various vasospasm of deep cerebral veins after SAH will be developed.
Subarachnoid hemorrhage / Cerebral vasospasm / Deep cerebral veins / Magenatic resonance imaging
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