Lipid infiltration in pacemaker cells and cell matrix of sinus node induced by atherosclerosis in rabbits
LI Na-Na, WANG Qiang-Zhi, ZHOU Li, ZHANG Gong-Qi
Chinese Journal of Clinical Anatomy ›› 2011, Vol. 29 ›› Issue (4) : 433-435.
Lipid infiltration in pacemaker cells and cell matrix of sinus node induced by atherosclerosis in rabbits
Objective To explore the effects of atherosclerosis on the morphological changes of rat sinoatrial node (SAN), especially the features of pacemaker cells and transitional cells under light microscopy and transmission electron microscopy. Methods 20 New Zealand white rabbits were randomly allocated to control group and hyperlipidemia group, with 10 animals in each group. The control animals were fed with routine forage, but animals of the hyperlipidemia group was fed with high lipid forage about 3 months. Histologic changes of SAN were studied through serial sections and transmission electron. Results Atherosclerotic plaques and extensive lipid infiltration appeared in myocardium tissue and cell matrix of hyperlipidemia animals separately. Transmission electron microscope revealed that a large number of lipid droplets aggregated in pacemaker cells, transitional cells, interstitial cells and interstitial matrix. Conclusions Atherosclerosis causes fat deposition in SAN. Lipid infiltration in SAN may damage impulse generation, transmission and distribution and thereby provide morphological basis for spontaneous activity.
Atherosclerosis / Pacemaker cell / Transitional cell / Lipid / Sinoatrial node / Rabbit
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