Research progress on the pathogenesis of chronic ankle instability&nbsp;

doi:10.13418/j.issn.1001-165x.2026.2.18

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Chinese Journal of Clinical Anatomy ›› 2026, Vol. 44 ›› Issue (2) : 239-241. DOI: 10.13418/j.issn.1001-165x.2026.2.18

Research progress on the pathogenesis of chronic ankle instability

Chen Liyu^1,2# , Zhang Xiurui^2#, Xiao Jin^1,2*

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Abstract

Chronic Ankle Instability (CAI) is a complex pathological condition triggered by acute ankle sprains, characterized by recurrent joint instability, functional impairments, and activity limitation. Although the clinical manifestations of CAI are widely acknowledged, its specific pathogenesis have not been fully clarified. This review systematically examines the pathogenesis of CAI, with a particular emphasis on its anatomical foundations, primary injuries due to ligamentous injury, pathomechanical impairments, sensory-perceptual impairments s, motor- behavioral impairments,. Additionally, it contrasts traditional classification approaches with emerging multidimensional models, highlighting the clinical significance of the comprehensive instability theory in assessment. This review offers valuable insights for advancing future research and optimizing clinical practice.

Key words

Chronic ankle instability / / / Ankle sprains / / / Anterior talofibular ligament / / / Pathogenesis / Pathomechanical impairments / / Sensory-perceptual impairments / Motor-behavioral impairments / Neurophysiological adaptations

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Chen Liyu , Zhang Xiurui, Xiao Jin. Research progress on the pathogenesis of chronic ankle instability [J]. Chinese Journal of Clinical Anatomy. 2026, 44(2): 239-241 https://doi.org/10.13418/j.issn.1001-165x.2026.2.18

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