Analysis of the efficacy and safety of autologous tissue reconstruction with V-NOTES in patients with pelvic organ prolapse

doi:10.13418/j.issn.1001-165x.2026.1.15

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Chinese Journal of Clinical Anatomy ›› 2026, Vol. 44 ›› Issue (1) : 96-103. DOI: 10.13418/j.issn.1001-165x.2026.1.15

Analysis of the efficacy and safety of autologous tissue reconstruction with V-NOTES in patients with pelvic organ prolapse

Guan Haifeng¹, Bao Erchen², Yu Nan¹*

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Abstract

Objective To analyze the effectiveness and safety of autologous tissue reconstruction via vaginal natural orifice transluminal endoscopic surgery (V-NOTES) in patients with pelvic organ prolapse (POP). Methods A total of 136 POP patients who had V-NOTES autologous tissue repair performed at our facility between September 2022 and September 2024 were enrolled into the research subjects. According to the pelvic organ prolapse quantitative staging method (POP-Q), the patients were split into two groups one year following surgery: an objective cure group (n=122) and a non-cure or recurrence group (n=14). Multivariate logistic regression was used to analyze the determinants of treatment outcome and risk variables for complications. Results According to POP-Q score, after treatment, 108 patients (79.41%) were at grade 0, 14 patients (10.29%) at grade I, 9 patients (6.62%) at grade II, and 5 patients (3.38%) at grade III. The objective cure rate after the operation was 89.71%. Complications occurred in 30 cases (22.06%). Preoperative high C-reactive protein (CRP) level (OR=1.587, 95%CI: 1.369-1.785, P<0.001), preoperative high white blood cell (WBC) level (OR=2.657, 95%CI: 1.695-5.269, P<0.001), and preoperative low PA level (OR=0.589, 95%CI: 0.327-0.853, P<0.001) were independent risk factors for non-cure or recurrence after POP treatment. The patient's previous surgical history of total hysterectomy (OR=1.256, 95%CI: 1.128-3.187, P<0.001) and previous surgical history of myomectomy (OR=2.654, 95%CI: 1.659-4.558, P<0.001) and a higher preoperative CRP level (OR=3.118, 95%CI: 2.147-5.436, P<0.001) were independent risk factors for complications. Conclusions V-NOTES autologous tissue repair, as an emerging treatment strategy, showed high safety and effectiveness in the treatment of POP. Controlling the inflammatory response and maintaining a good nutritional status before the operation had a positive effect on the treatment outcome.

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Pelvic organ prolapse / / / Vaginal natural orifice transluminal endoscopic surgery / / / Autologous tissue reconstruction / / / Effectiveness

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Guan Haifeng, Bao Erchen, Yu Nan. Analysis of the efficacy and safety of autologous tissue reconstruction with V-NOTES in patients with pelvic organ prolapse[J]. Chinese Journal of Clinical Anatomy. 2026, 44(1): 96-103 https://doi.org/10.13418/j.issn.1001-165x.2026.1.15

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