Effects of continuous multi-site injection and fan-shaped injection on skin at the injection site

doi:10.13418/j.issn.1001-165x.2025.6.11

PDF(2606 KB)

Chinese Journal of Clinical Anatomy ›› 2025, Vol. 43 ›› Issue (6) : 693-696. DOI: 10.13418/j.issn.1001-165x.2025.6.11

Effects of continuous multi-site injection and fan-shaped injection on skin at the injection site

Wu Weizi¹, Hu Yu^1,2, Zhang Luyu¹, You Xida³, Zhang Yuchen¹, Wu Chengjie^1,4*, Bi Zhenyu¹*

Author information +

History +

Abstract

Objective To investigate the effects of two commonly used injection methods - continuous multi-site and fan-shaped injection-on the puncture site. Methods Both injection techniques were administered to simulate clinical procedures on C57 mice. The effects of two different injection methods on the appearance of the puncture site, as well as the histological and molecular proteomic aspects. Results After one week of the two different puncture injection methods, there was no significant difference in the general appearance of the puncture sites of the mice. Histological examination demonstrated preserved tissue integrity with no signs of inflammation, and the RT-qPCR analysis of inflammatory-related factors showed no statistically significant difference (P>0.05). Conclusions Continuous multi-site injection and fan-shaped injection don't show significant differences in terms of wound healing, histological changes, and expression of inflammatory factors in mice.

Key words

Beauty injection / / / Continuous multi-site injection / / / Fan-shaped injection

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

Wu Weizi, Hu Yu, Zhang Luyu, You Xida, Zhang Yuchen, Wu Chengjie, Bi Zhenyu. Effects of continuous multi-site injection and fan-shaped injection on skin at the injection site[J]. Chinese Journal of Clinical Anatomy. 2025, 43(6): 693-696 https://doi.org/10.13418/j.issn.1001-165x.2025.6.11

References

[1] 刘毅. 重视注射美容技术研究进一步提高安全性和有效性 [J]. 中华医学美学美容杂志, 2021, 27(5): 358-360.DOI:10.3760/cma.j.issn.1671-0290.2021.05.002.
Liu Y. Advances in the Prevention and Management of Complications in Cosmetic Injections[J]. Chinese Journal of Medical Aesthetics Cosmetology, 2021, 27(5): 358-360. DOI:10.3760/cma.j.issn.1671-0290.2021.05.002.
[2] de Maio M, Wu WTL, Goodman GJ, et al. Facial Assessment and Injection Guide for Botulinum Toxin and Injectable Hyaluronic Acid Fillers: Focus on the Lower Face [J]. Plast Reconst Surg, 2017, 140(3): 393e-404e. DOI:10.1097/prs.0000000000003646.
[3] Zhang Y, Zou J, Yuan Y, et al. Contouring and augmentation of the temple using stromal vascular fraction gel grafting [J]. Front Surg, 2022, 9: 893219. DOI:10.3389/fsurg.2022.893219.
[4] Khorasani M, Janbaz P. Clinical evaluation of autologous fat graft for facial deformity: a case series study [J]. J Korean Assoc Oral Maxillofac Surg,2021,47(4):286-290. DOI:10.5125/jkaoms. 2021.47. 4.286.
[5] Lin JY, Lin CY. Fan-Dotting injection technique: A simple method for infraorbital rejuvenation using injectable Poly-D,L-lactic acid [J]. J Cosmet Dermatol, 2023, 22(5): 1708-1709. DOI:10.1111/jocd.15624.
[6] 王刚, 刘毅. 注射美容并发症的防治进展 [J]. 中华医学美学美容杂志,2024,30(2):105-110. DOI:10.3760/cma.j.issn.1671-0290.2024.02. 004.
Wang G, Liu Y. Advancing injection techniques to enhance safety and efficacy[J]. Chinese Journal of Medical Aesthetics Cosmetology, 2024, 30(2): 105-110. DOI:10.3760/cma.j.issn.1671-0290.2024.02.004
[7] 梁虹. 注射美容技巧及注意事项 [J]. 皮肤病与性病, 2014, 36(2): 72-73. DOI:10.3969/j.issn.1002-1310.2014.02.005.
Liang H. Techniques and Precautions for Cosmetic Injections [J]. Dermatology and Venereology, 2014, 36(2): 72-73.DOI:10.3969/j.issn.1002-1310.2014.02.005.
[8] Bass LS. Injectable Filler Techniques for Facial Rejuvenation, Volumization, and Augmentation [J]. Facial Plast Surg Clin North Am, 2015, 23(4): 479-488. DOI:10.1016/j.fsc.2015.07.004.
[9] Trinh LN, Grond SE, Gupta A. Dermal Fillers for Tear Trough Rejuvenation: A Systematic Review [J]. Facial Plast Surg, 2022, 38(3): 228-239. DOI:10.1055/s-0041-1731348.
[10]郑旭东, 柳大烈, 麦跃. 钝针扇形连续注射法在肉毒毒素治疗咬肌肥大中的应用 [J]. 中国美容医学, 2013, 22(22): 2183-2185. DOI:10.15909/j.cnki.cn61-1347/r.2013.22.012.
Zheng JD, Liu DL, Mai Y. The use of microcannula in treatment of masseter hypertrophy with BOTOX[J]. Chinese Journal of Aesthetic Medicine, 2013, 22(22): 2183-2185. DOI:10.15909/j.cnki.cn61-1347/r.2013.22.012.
[11]陈波, 路会, 马力, 等. 钝针皮下层扇形注射透明质酸矫正面颊部凹陷 [J]. 中国美容医学, 2018， 27(3): 18-20. DOI:10.15909/j.cnki.cn61-1347/r.002246
Chen B, Lu H, Ma L, et al. Correction of check depression by fanshapod hyaluronic acid injection in subcutaneous layers with blunt needle [J]. Chinese Journal of Aesthetic Medicine, 2018, 27(3): 18-20.DOI:10.15909/j.cnki.cn61-1347/r.002246.
[12]Grellner W, Georg T, Wilske J. Quantitative analysis of proinflammatory cytokines (IL-1beta, IL-6, TNF-alpha) in human skin wounds [J]. Forensic SCI Int, 2000, 113(1-3): 251-264. DOI:10.1016/s0379-0738(00)00218-8.