Observation on the therapeutic effect of acupuncture on the gallbladder contraction function of patients after gallbladder-preserving cholecystolithotomy

doi:10.13418/j.issn.1001-165x.2025.5.18

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Chinese Journal of Clinical Anatomy ›› 2025, Vol. 43 ›› Issue (5) : 612-617. DOI: 10.13418/j.issn.1001-165x.2025.5.18

Observation on the therapeutic effect of acupuncture on the gallbladder contraction function of patients after gallbladder-preserving cholecystolithotomy

Wang Sangui^1,2, Chen Lifang¹, Wang Haifeng¹, Yan Bowen³, Wang Zhi⁴, Wang Ni¹, Li Jiahao¹, Li Yun⁵, Wang Quanlei^1,2,4*

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Abstract

Objective To investigate the effect of acupuncture on the gallbladder contraction function in patient after gallbladder-preserving cholecystolithotomy (GPC). Methods Total seventy cases of GPC patients, including acupuncture group (n=41) and non-acupoint (sham-acupuncture) group (n=29) were enrolled in this study. In acupuncture group, acupuncture was applied to Yanglingquan (GB34), Dannangxue (EX-LE6), Qimen (LR14), Zusanli (ST36), while the filiform needle was touched but not inserted skin 2 cun around the corresponding acupoints for the sham-acupuncture group, and the needles were retained for 30 min. Acupuncture was preformed once daily and total for consecutive 7 days in these two groups. A color Doppler ultrasound scanner was used to detect the gallbladder ejection fraction (GBEF) before and 1, 3, 6 months after acupuncture operation. Serum cholecystokinin-A receptor (CCKAR) and gastrin were detected by enzyme-linked immunosorbent assay at 1 months after acupuncture stimulation. Results The GBEF were markedly increased compared to the baseline. Compare to sham-acupuncture group, the GBEF were significantly higher at 1 month and 3 months (P<0.001), while that were similar at 6 months in acupuncture group. Serum CCKAR were increased but not significant (P>0.05), whereas gastrin significantly decreased in the acupuncture group (P<0.01). Conclusions Acupuncture can effectively promote GBEF which might be regulated though CCKAR/gastrin signals.

Key words

Acupuncture; / Gallbladder contractile function; / Gallbladder ejection fraction; / Gallbladder-preserving cholecystolithotomy

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Wang Sangui, Chen Lifang, Wang Haifeng, Yan Bowen, Wang Zhi, Wang Ni, Li Jiahao, Li Yun, Wang Quanlei. Observation on the therapeutic effect of acupuncture on the gallbladder contraction function of patients after gallbladder-preserving cholecystolithotomy[J]. Chinese Journal of Clinical Anatomy. 2025, 43(5): 612-617 https://doi.org/10.13418/j.issn.1001-165x.2025.5.18

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