Objective To compare the clinical outcomes of fresh cleavage embryo transfer and blastocyst transfer in the gonadotropin-releasing hormone (GnRH) antagonist protocol. Methods The clinical data of 1249 women undergoing GnRH antagonist protocol cycle were retrospectively analyzed, including 871 cases of fresh cleavage embryo transfer and 378 cases of fresh blastocyst transfer. Results There was no significant difference in age, duration of infertility and BMI between the two group (P>0.05). The baseline FSH, total dosage of Gn and FSH level on trigger day in cleavage embryo transfer group were significantly higher than those in blastocyst transfer group (P<0.05). The baseline LH, AMH, AFC and E2, P level on trigger day in cleavage embryo transfer group were significantly lower than those in blastocyst transfer group (P<0.05). The total number of oocytes retrieved, matured oocyte, high-quality embryos in cleavage embryo transfer group were significantly lower than those in blastocyst transfer group, with significant difference (P<0.05). The number of embryos transfer and the multiple pregnancy rate in cleavage embryo transfer group was significantly higher than those in blastocyst transfer group, the implantation rate in cleavage embryo transfer group were significantly lower than that in blastocyst transfer group, with significant difference (P<0.05). There was no significant difference in the clinical pregnancy rate, miscarriage rate, ectopic pregnancy rate, live birth rate, the incidence of moderate-severe OHSS, GDM and hypertensive disorder complicating pregnancy and the singleton birth weight between the two groups (P>0.05). Conclusions In the GnRH antagonist protocol cycle, fresh blastocyst transfer can reduce the multiple pregnancy rate and achieve good clinical outcome.
Key words
GnRH antagonist protocol /
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Fresh embryo transfer /
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Cleavage embryo transfer /
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Blastocyst transfer
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