Objective To compare the predictive efficacy of the vertebral fracture risk model (TVF) and fracture risk assessment tool (FRAX) in stratifying fracture risk among osteoporotic patients. Methods A single-center prospective real-world study included 91 patients from the Osteoporosis Clinic of Nanfang Hospital (April-June 2022), with 73 cases of completing 1-year follow-up. After collecting the baseline data, the patients were classified into two groups based on the FRAX model: low-risk group (53 cases) and high-risk group (38 cases), classified into three groups based on TVF model: low- (n=9), medium- (n=39), and high-risk (n=25) groups. Fracture incidence was followed-up every 3 months. Results Among the two groups of models, there were significant differences in bone mineral density T-scores and fracture history between the risk stratification groups (P<0.05), and the age difference was significant in the FRAX group. The FRAX high-risk group showed lower EQ-5D-5L scores in mobility (2.1±0.8 vs 1.3±0.6), daily activities (2.4±0.7 vs 1.5±0.5), and total scores (8.2±1.9 vs 6.1±1.5, P<0.05). Actual fracture incidence: 22.6% in FRAX high-risk group (7/31) vs 0%in low-risk group (0/42); 24% in TVF high-risk group (6/25) vs 2.5% in medium-risk group (1/39) vs 0% in low-risk group (0/9). Conclusions Both TVF and FRAX have the efficacy of stratifying fracture risk, to some extent, FRAX can distinguish the quality of life of patients, but there is also the possibility of underestimating the fracture risk. As a model that focuses on studying the risk of osteoporotic vertebral fractures, TVF's effectiveness and ease of application lay the foundation for future research.
Key words
Immediate vertebral fracture; /
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Osteoporosis; /
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Postmenopausal women
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