Objective To provide new imaging diagnostic basis for the early diagnosis of Alzheimer's disease (AD). Methods Sixty normal old people with check of different ages and 60 elderly AD of different degrees were selected by arterial spin labeling(ASL) perfusion weighted imaging examination. At the image post-processing workstation, the regions of interest (ROI) of brain structure were divided, and the cerebral blood flow (CBF) value of ROI was measured. The CBF values of brain structure ROI among the different old ages groups and its corresponding ROI in AD group were compared. Results There were statistically significant in the CBF values among of the different old ages group of the cingulate gyrus, parahippocampal gyrus, hippocampus, orbital part of frontal lobe, temporal pole of temporal lobe, insula lobe and amygdaloid body in all age groups (P<0.05), and the CBF value of ROI decreased gradually with the increase of age. The CBF values in the observation group of the cingulate gyrus, parahippocampal gyrus, hippocampus, orbital part of frontal lobe, temporal pole of temporal lobe, insula lobe and amygdaloid body were (56.49±5.73) mL/100g·min, (49.40±3.51) mL/100g·min, (46.57±4.27) mL/100g·min, (58.59±4.67) mL/100g·min, (57.66±4.80) mL/100g·min, (56.47±3.79) mL/100g·min, (45.61±3.53) mL/100g·min, respectively. There were statistically significant in the CBF value of ROI among the observation group and the mild, moderate, severe old AD group (P<0.05), and the CBF value of ROI decreased gradually with the severity of AD lesion. Conclusions The hippocampus and cingulate gyrus of limbic system are the hypoperfusion sites in the brain structure of AD patients, the CBF value of ASL perfusion weighted imaging before cerebral cortex atrophy can reflect the function of brain structure in AD patients.
Key words
Brain structure /
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Arterial spin labeled perfusion weighted imaging /
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Elderly /
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Cerebral blood flow value /
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Alzheimer's disease
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