Mechanism analysis of Resolvin D1 in treating intracerebral hemorrhage

doi:10.13418/j.issn.1001-165x.2025.3.13

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Chinese Journal of Clinical Anatomy ›› 2025, Vol. 43 ›› Issue (3) : 328-334. DOI: 10.13418/j.issn.1001-165x.2025.3.13

Mechanism analysis of Resolvin D1 in treating intracerebral hemorrhage

Zhang Ziyou^1,3, Lv Xiaoyu¹, Zhou Xinpei¹, Li Zhuang², Zhang Bensi¹*

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Abstract

Objective To explore the mechanism of Resolvin D1 in the treatment of intracranial hemorrhage by using network pharmacology and molecular docking techniques. Methods The target information related to RvD1 and intracranial hemorrhage was obtained from five databases: PubChem, TargetNet, Stitch, Disgenet and GeneCards. Then, the protein interaction analysis and core target screening were carried out using String database and Cytoscape software. The enrichment analysis of Go and KEGG was performed at the same time, and finally the molecular docking experiment was conducted for verification. Results A total of 115 RvD1-related target genes and 1705 intracranial hemorrhage targets were obtained, and there were 60 overlapping genes among them. The PPI network analysis results showed a complex network of 60 nodes and 554 edges. The top 10 core targets were IL6, IL1B, TNF, IL10, TLR4, IFNG, STAT3, CD4, MMP9, and CCL2. Molecular docking test showed that RvD1 has strong binding affinity for these target proteins. Conclusions In the treatment of intracranial hemorrhage, RvD1 may affect the inflammatory response and protein binding process by regulating multiple target genes, and plays a role in multiple signaling pathways.

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Network pharmacology / / / Molecular docking / / / Resolvin D1 / / / Intracranial hemorrhage

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Zhang Ziyou, Lv Xiaoyu, Zhou Xinpei, Li Zhuang, Zhang Bensi. Mechanism analysis of Resolvin D1 in treating intracerebral hemorrhage[J]. Chinese Journal of Clinical Anatomy. 2025, 43(3): 328-334 https://doi.org/10.13418/j.issn.1001-165x.2025.3.13

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