Expression and clinical significance of XKRX in colorectal cancer
PAN Yang-jian，GAO yuan，LIU Xiao-long， SUN Jing-bo， HUANG Xiao-ping， LIU Li-xin
Chinese Journal of Clinical Anatomy ›› 2018, Vol. 36 ›› Issue (2) : 202-205.
Expression and clinical significance of XKRX in colorectal cancer
Objective To explore the expression and clinical significance of XK related, X-linked (XKRX) in colorectal cancer tissue. Methods The gene expression of XKRX and corresponding clinical data in colorectal cancer in TCGA public database were collected to make retrospective analysis and survival analysis. Quantitative real-time PCR and western blot were conducted to assess the expression of XKRX in 21 cases of colorectal cancer tissues. Results We found that the expression level of XKRX in colorectal cancer tissues was significantly higher than that of adjacent tissues (P<0.0001). The mRNA and protein expression level of XKRX in colorectal cancer tissues were significantly higher than that of the tissues adjacent to carcinoma. There was no significant difference between XKRX expression and gender (P= 0.9034), age (P=0.886), TMN stage (P=0.3979), lymph node metastasis (P=0.7995) and distant metastasis (P=0.6032). However, the survival time of the group with XKRX high expression was significantly lower than that of the group with low expression (P=0.0075). Conclusion Our data shows that XKRX is up-regulated in colorectal cancer tissues and may play a role in the proto-oncogene, which may affect the malignant progression of colorectal cancer and reduce the survival time of patients.
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