收稿日期: 2014-09-27
网络出版日期: 2015-08-14
基金资助
滨州医学院科技计划（BY2011KJ083）
Development of the human fetal cerebellum in the second and third trimester
Received date: 2014-09-27
Online published: 2015-08-14
目的 应用胎儿标本MR图像观察14～40周胎儿小脑结构发育情况。 方法 87例无中枢神经系统疾病的胎儿，孕龄为14~40周，行3.0T磁共振扫描，根据所得横矢冠图像分析小脑各结构发育情况。 结果 T2WI图像观察可见各结构出现时间不同：16周时可见齿状核，17周时被盖-小脑蚓角闭合，20周时原裂出现，22周时锥体前裂，第四脑室显示清晰，24周时次裂，后外侧裂出现。孕晚期，小脑体积增长迅速，前后叶比例由大变小。 结论 3.0T磁共振图像可以较清晰地显示孕中后期胎儿小脑各结构的发育情况，以此为依据可为临床宫内胎儿小脑发育状况的诊断与评估提供解剖和影像学依据。
刘菲 , 刘树伟 , 李振平 , 张忠和 . 孕中晚期胎儿小脑形态发育的MRI研究[J]. 中国临床解剖学杂志, 2015 , 33(4) : 399 -402 . DOI: 10.13418/j.issn.1001-165x.2015.04.006
Objective To observe the development of human fetal cerebellum with MRI in the second and third trimester. Methods 87 fetuses that had no morphological brain disorder at 14~40 weeks of gestation were scaned using 3.0T MRI. Transverse, sagittal and coronal images were used to analyze the development of cerebellar structures. Results From images, we found that the dentate nucleus was visible at week 16 of gestation. From week 17, the tegmento-vermian angle was invisible. The prepyramidal fissure and the fourth ventricle could be recognized at week 22, whereas the primary fissure was visible at week 20. The second fissure and posterolateral fissure were recognized at week 24. In second and third trimester, the shape and the fissures of cerebellum came into being and the CV also grew rapidly; the ratio of the anterior lobe to the posterior lobe decreased with GA. Conclusions The development of the fetal cerebellum in the second and third trimester could be displayed by 3.0T MRI. This study could provide anatomical and imaging data concerning the development of the fetal cerebellum, which is valuable for clinical diagnosis and evaluation of fetal development in vivo.
Key words： Fetal; Cerebellum; MR; Specimen
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