临床研究

新型仿生人工神经导管修复周围神经缺损的初步临床观察

  • 王华松 ,
  • 吴刚 ,
  • 黄继锋 ,
  • 张伟才
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  • 广州军区武汉总医院骨科,  武汉   430070
王华松(1974-),男,湖北荆州人,医学博士,主要从事显微外科的临床与基础工作,Tel:(027)50772548

收稿日期: 2014-02-13

  网络出版日期: 2014-12-04

Preliminary clinical observation of repairing peripheral nerve defect by a novel artificial nerve conduit

  • WANG Hua-Song ,
  • TUN Gang ,
  • HUANG Ji-Feng ,
  • ZHANG Wei-Cai
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  • Department of Orthopedics, Wuhan General Hospital of Guangzhou Command, Wuhan 430070, China

Received date: 2014-02-13

  Online published: 2014-12-04

摘要

目的 探讨课题组构建的一种新型仿生人工神经导管修复人周围神经缺损的临床疗效。  方法 对2011年12月至2012年12月期间的上肢周围神经缺损病例使用该神经导管进行手术修复并进行随访,以“中华医学会手外科学会上肢部分功能评定试用标准”对相应的神经功能进行评估。  结果 共计8例病例均获得随访,6例神经功能有一定改善,其中优2,良3例,可1例。  结论 该神经导管修复周围神经缺损具有良好的效果,为一种较为理想的周围神经缺损的修复材料。

本文引用格式

王华松 , 吴刚 , 黄继锋 , 张伟才 . 新型仿生人工神经导管修复周围神经缺损的初步临床观察[J]. 中国临床解剖学杂志, 2014 , 32(6) : 735 -738 . DOI: 10.13418/j.issn.1001-165x.2014

Abstract

Objective To explore the clinical effect of  a novel bionic  artificial nerve conduit on repairing defect of  peripheral nerves. Methods From December, 2011 to December, 2012, patients suffered from peripheral nerve defect of upper limbs were treated by surgical treatments using the  artificial nerve conduits and followed up.  “The Upper Extremity Functional Evaluation Standard by Hand Surgery Branch Of Chinese Medical Association” was used to evaluate the neural function. Results A total of 8 cases received following-up. Neural function of 6 cases was partially restored among which 2 cases got excellent result, 3 cases good and 1 cases fair. Conclusion This novel nerve conduit showed good effect on defect of  peripheral nerve and consequently was an ideal repairing materials for peripheral nerve defect.

参考文献


[1]  Jifeng H, Dezhong L, Qiongjiao Y, et al. Evaluation of PRGD/FK506/NGF conduits for peripheral nerve regeneration in rats
[J]. Neurol India, 2010, 58 (1): 384-391.

[2]  向杰, 黄继锋, 李德忠, 等. 新型仿生人工神经导管诱导犬周围神经再生过程的组织学观察
[J]. 中国组织工程研究, 2012, 16 (21) :3801-3805.

[3]  黄继锋, 征华勇, 李世普,等. RGD 多肽接枝聚复合导管桥接神经缺损的实验研究
[J]. 中华手外科杂志, 2009, 25 (3):154-157.

[4] GR Evans. Peripheral nerve injury: a review and approach to tissue engineered constructs
[J]. Anat Rec, 2001, 263 (4): 396-404.

[5] Dubey N, Letourneau P, Tranquillo R. Guided neurite elongation and Schwann cell invasion into magnetically aligned collagen in simulated peripheral nerve regeneration
[J]. Exp Neurol,1999, 158 (2): 338-350.

[6] Nectow AR, Marra KG, Kaplan DL. Biomaterials for the development of peripheral nerve guidance conduits
[J]. Tissue Eng Part B Rev, 2011, 18 (1): 40-50.

[7] Bell JH, Haycock JW. Next generation nerve guides: materials, fabrication, growth factors, and cell delivery
[J]. Tissue Eng Part B Rev, 2011, 18 (2): 116-128.

[8] Kehoe S, Zhang X, Boyd D. FDA approved guidance conduits and wraps for peripheral nerve injury: a review of materials and efficacy
[J]. Injury, 2012,43,(5): 553-572.

[9] Whitlock EL, Tuffaha SH, Luciano JP, et al. Processed allografts and type I collagen conduits for repair of peripheral nerve gaps
[J]. Muscle  nerve, 2009, 39(6): 787-799.

[10] Gu J, Hu W, Deng A, et al. Surgical repair of a 30 mm long human median nerve defect in the distal forearm by implantation of a chitosan-PGA nerve guidance conduit
[J]. J Tissue Eng Regen Med, 2012, 6(2): 163-168.

[11] Lundborg G, Rosen B, Dahlin L, et al. Tubular repair of the median or ulnar nerve in the human forearm: a 5-year follow-up
[J]. J Hand Surg Br,2004, 29 (2): 100-107.

[12] Moradzadeh A, Borschel GH, Luciano JP, et al. The impact of motor and sensory nerve architecture on nerve regeneration
[J]. Exp Neurol,2008, 212 (2): 370-376.

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