纳米羟基磷灰石人工骨在骨缺损修复中的临床应用研究
收稿日期: 2013-06-10
网络出版日期: 2014-04-21
基金资助
深港创新圈资助计划项目(SG200810200101A), 深圳市科技研发项目(GJHZ20130412153906739, CXZZ20130321152713220), 广东省医学科研基金项目(B2012320), 广东省教育厅育才项目(2012LYM_0120)
Clinical application study of Nano-Hydroxyapatite artificial bone in bone defect repair
Received date: 2013-06-10
Online published: 2014-04-21
目的 探讨纳米羟基磷灰石人工骨（Nano-HA）修复骨缺损的临床效果。 方法 回顾性分析了2009年9月~2012年6月采用Nano-HA人工骨治疗的27例骨缺损患者，骨缺损范围为0.3cm×1.0cm ~3.0cm×6.5cm，人工骨植入量为3~15 g。部位包括肱骨、桡骨、尺骨、股骨、胫骨、跟骨。骨缺损原因包括骨折22例，骨肿瘤5例。分别在术后1周、1个月和3个月进行临床和X线片检查，观察治疗效果。 结果 随访时间11个月～26个月，平均18.5个月，骨缺损区Nano-HA与宿主骨直接愈合，相容性好，与原骨界面间无间隙，术后观察未见不良反应。 结论 Nano-HA人工骨具有良好的生物相容性，是一种理想的骨缺损修复材料。
王大平 , 熊建义 , 朱伟民 , 黄江鸿 , 段莉 , 陈洁琳 , 张巨峰 . 纳米羟基磷灰石人工骨在骨缺损修复中的临床应用研究[J]. 中国临床解剖学杂志, 2014 , 32(2) : 206 -209 . DOI: 10.13418/j.issn.1001-165x.2014
Objective To study the clinical effect of nano-hydroxyapatite(Nano-HA) artificial bone on repairing bone defects. Methods From Sep. 2009 to Jun. 2012, 27 cases of bone defect were collected retrospectively. The bone defect ranged from 0.3cm×1.0cm to 3cm×6.5cm, which including the bone defects of humerus, radius, ulna, femur, tibia, and calcaneus. Among them, 22 cases suffered from fractures and 5 cases tumors. All patients were treated with Nano-HA artificial bone. Observation was applied on healing of wounds and X-ray exams preoperatively and postoperatively. Results The patients were followed up from 11 month to 26 months （averagely 18.5 months）. X-ray photo showed an integrity interface between Nano-HA and bone. Primary healing was obtained in all cases without any complication. Conclusions The Nano-HA artificial bone has a good biocompatibility. It may be an ideal artificial material to reconstruct bone defect.
Key words： Nano-material; Lydroxyapatite; Artificial bone; Bone defect
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