新生儿胼胝体大小及形状与胎龄的相关性研究

doi:10.13418/j.issn.1001-165x.2014.01.008

中国临床解剖学杂志 ›› 2014, Vol. 32 ›› Issue (1): 31-35.doi: 10.13418/j.issn.1001-165x.2014.01.008

新生儿胼胝体大小及形状与胎龄的相关性研究

刘瑞可¹，　刘芳²，　任常军³，　李建英¹，　吴秀芳¹

1.沧州市人民医院，沧州 061000；　2.中国人民解放军白求恩国际和平医院，石家庄 050082；
3.河北医科大学第一医院，石家庄 050051

收稿日期:2013-06-19 出版日期:2014-01-25 发布日期:2014-02-11
作者简介:刘瑞可（1982-），女，河北沧州人，主治医师，硕士，主要从事新生儿疾病方面的研究，Tel：（0317）3521272
基金资助:
2012年河北省人口和计划生育委员会计划项目(2012-A15)

The relationship between the size, shape of corpus callosum and gestational age in neonatal infants

LIU Rui-ke¹, LIU Fang², REN Chang-jun³, LI Jian-ying¹, WU Xiu-fang¹

1. Cangzhou People’s Hospital, Cangzhou 061000; 2. Bethune International Peace Hospital, Shijiazhuang 050082; 3. The First Hospital of Hebei Medical University, Shijiazhuang 050051, China

Received:2013-06-19 Online:2014-01-25 Published:2014-02-11

摘要/Abstract

摘要：

目的　通过高场MRI检测不同胎龄新生儿出生时胼胝体的面积、偏心率及斜率，为早期评价和改善脑发育提供参考。方法　从沧州市人民医院提取符合研究条件的新生儿头颅高场MRI图像286例，勾画胼胝体后使用MATLAB R2010a中的图像处理函数进行测量，得到胼胝体面积、偏心率及斜率并作统计学分析。结果　胼胝体面积与胎龄的相关系数为0.61（P＜0.001），最适曲线为二次曲线Y=0.132X2-6.179X+141.759，决定系数为0.37（P＜0.001）；偏心率与胎龄的相关系数为0.25（P＜0.001），最适曲线为直线方程Y=0.009X+0.319，决定系数为0.07（P＜0.001）；后部斜率与胎龄的相关系数为0.27（P＜0.001），最适曲线为直线方程Y=0.005X+0.349，决定系数为0.07（P＜0.001）。结论　新生儿胎龄愈小，胼胝体愈小且愈圆。

关键词: 大脑, 胼胝体, 磁共振成像, 新生儿, 胎龄

Abstract:

Objective 　The aim of this study was to study the pattern of callosal development by MRI to investigate neonatal corpus callosum size and shape in different gestational ages and to analyze the relationship between the area, eccentricity ratio and posterior skew of neonatal corpus callosum and gestational age, so that reference for early evaluation of the development of brain can be provided. Method 286 eligible high field brain MR images of neonates were selected. All corpus callosums were sketched in the MR images. And then, all data were analyzed by Image Processing Function of MATLAB R2010a. Corpus callosum area, eccentricity ratio and skew in 286 neonates were obtained and analyzed statistically, respectively. Result Pearson correlation analysis indicated the positive linear correlation between the corpus callosum area and gestational age (r=0.61, P<0.001). The corpus callosum area formed a quadratic curve with the gestational age, which was Y=0.132X2-6.179X+141.759(R2=0.37, P＜0.001). Spearman rank correlation analysis indicated the positive linear correlation between the eccentricity ratio of corpus callosum and gestational age (r=0.25，P＜0.001). The eccentricity ratio of corpus callosum formed a linear equation with the gestational age, which was Y=0.009X+0.319 (R2=0.07，P＜0.001). Pearson correlation analysis indicated the positive linear correlation between the skew of posterior corpus callosum and gestational age (r=0.27，P＜0.001). The skew of posterior corpus callosum formed a linear equation with the gestational age, which was Y=0.005X+0.349 (R2=0.07，P＜0.001). Conclusion The results of this study suggest that the smaller the gestational age of the newborn, the smaller and circular the corpus callosum.

Key words: Brain, Corpus callosum, Magnetic resonance imaging, Neonate, Gestational age

中图分类号:

R722.19

刘瑞可, 刘芳, 任常军, 李建英, 吴秀芳. 新生儿胼胝体大小及形状与胎龄的相关性研究[J]. 中国临床解剖学杂志, 2014, 32(1): 31-35.

LIU Rui-Ge, LIU Fang, LIN Chang-Jun, LI Jian-Yang, TUN Xiu-Fang. The relationship between the size, shape of corpus callosum and gestational age in neonatal infants[J]. Chinese Journal of Clinical Anatomy, 2014, 32(1): 31-35.

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新生儿胼胝体大小及形状与胎龄的相关性研究

The relationship between the size, shape of corpus callosum and gestational age in neonatal infants

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