斜外侧腰椎间融合术治疗退行性腰椎管狭窄症疗效及对患者氧化应激指标影响

doi:10.13418/j.issn.1001-165x.2022.4.22

摘要/Abstract

摘要： 目的探讨斜外侧腰椎间融合术（oblique lateral interbody fusion，OLIF）对退行性腰椎管狭窄症（degenerative lumbar spinal stenosis，DLSS）的治疗效果。方法选取我院DLSS患者103例，按手术方式分为OLIF组（n=51，行OLIF），腰椎后路减压内固定融合术（posterior lumbar intervertebral fusion，PLIF）组（n=52，行PLIF）。对比两组手术情况、疗效与围手术期血清炎症因子、氧化应激指标、脊髓功能、腰腿疼痛（VAS）、腰椎功能（JOA）。结果 OLIF组围手术期指标、术后1年疗效优于PLIF组（P<0.05）；OLIF组术后1 d、3 d血清炎症因子水平低于PLIF组（P<0.05）；OLIF组术后1 d、3 d血清晚期蛋白氧化产物、丙二醛水平低于PLIF组，超氧化物歧化酶水平高于PLIF组（P<0.05）；OLIF组术后6个月、1年胫神经和腓总神经传导速度、JOA评分高于PLIF组，潜伏期、腰腿疼痛VAS评分低于PLIF组（P<0.05）。结论 OLIF治疗DLSS效果显著，创伤更轻微。

关键词: 斜外侧腰椎间融合术； , , 腰椎后路减压内固定融合术； , , 炎症因子； , , 氧化应激

Abstract: Objective To investigate the effect of oblique lateral interbody fusion (OLIF) in the treatment of degenerative lumbar spinal stenosis (DLSS). Methods A total of 103 DLSS patients in our hospital were selected. According to the treatment method, they were divided into an OLIF group (n=51, OLIF operation), a posterior lumbar intervertebral fusion (PLIF) group (n=52, PLIF operation). The curative effect, surgical conditions and perioperative serum inflammatory factors, oxidative stress indicators, spinal cord function, the Visual Analogue Scale (VAS), the Japanese Orthopedic Association (JOA) were compared between the two groups. Results The perioperative index and the effect of 1 year after operation in the OLIF group were better than those in the PLIF group (P<0.05). The levels of serum inflammatory factors in the OLIF group were lower than those in the PLIF group at 1 day and 3 days after operation (P<0.05). The levels of serum advanced oxidation protein products (AOPP) and malondialdehyde (MDA) in the OLIF group were lower than those in the PLIF group at 1 and 3 days after the operation, and the superoxide dismutase (SOD) level was higher than that in the PLIF group (P<0.05). The nerve conduction velocity (NCV) level and JOA score of the tibial nerve and common peroneal nerve in the OLIF group were higher than those in the PLIF group at 6 months and 1 year after the operation, while the latency (DL) and the VAS scores of waist and leg pain were lower than those of the PLIF group (P<0.05). Conclusions OLIF is effective in the treatment of DLSS, with less trauma.

Key words: Oblique lateral interbody fusion; , , Posterior lumbar intervertebral fusion; , , Inflammatory factors; , , Oxidative stress

中图分类号:

R687.3

李锐, 许财元, 孙贺, 张义龙. 斜外侧腰椎间融合术治疗退行性腰椎管狭窄症疗效及对患者氧化应激指标影响[J]. 中国临床解剖学杂志, 2022, 40(4): 491-496.

Li Rui, Xu Caiyuan, Sun He, Zhang Yilong. Effect and prognosis of oblique lateral interbody fusion in the treatment of degenerative lumbar spinal stenosis and its influence on oxidative stress index levels[J]. Chinese Journal of Clinical Anatomy, 2022, 40(4): 491-496.

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