SD大鼠视网膜中央动脉的应用解剖学研究

中国临床解剖学杂志 ›› 2013, Vol. 31 ›› Issue (3): 279-282.

SD大鼠视网膜中央动脉的应用解剖学研究

万炜^1,2，　刘政海²，　伍校琼¹，　王晓晟¹，　罗学港¹

1.中南大学基础医学院人体解剖学与神经生物学系，长沙 410013；　2.南华大学医学院解剖学教研室，湖南衡阳 421001

收稿日期:2013-01-20 出版日期:2013-05-25 发布日期:2013-06-06
通讯作者: 罗学港，教授，博士生导师，E-mail：xgluo@xysm.net E-mail:david-wan@163.com
作者简介:万炜（1968-），男，湖南临澧人，副教授，博士，主要从事中枢神经损伤与再生研究，Tel:（0734）8281971
基金资助:
国家自然科学基金（30671100）；湖南省自然科学基金（10JJ1046）

Applied anatomic study about the central retinal artery in SD rats

WAN Wei ^1,2, LIU Zheng-hai², WU Xiao-qiong¹, WANG Xiao-sheng¹, LUO Xue-gang¹

1.Department of Human Anatomy and Neurobiology, Xiangya Medical College of Central South University, Changsha 410013, China；2.Department of Human Anatomy, University of South China, Hengyang 421001, China

Received:2013-01-20 Online:2013-05-25 Published:2013-06-06

摘要/Abstract

摘要：

目的　为建立稳定可靠的视神经损伤动物模型寻求解剖学依据。方法　用红色乳胶灌注技术显示正常SD大鼠视网膜中央动脉的来源、分支、分布及其与视神经的关系，并采用体视显微镜摄片测量；明胶墨汁灌注技术显示距眼球后极2.0 mm或6.0 mm处横断视神经后视网膜的血供。结果　视网膜中央动脉及其分支在视神经鞘内始终与视神经干伴行，视网膜中央动脉起始部到眼球后极的距离为(5.784±0.054)mm；距离眼球后极6.0 mm处鞘内视神经横断组大鼠视网膜单位面积血管数目高于其他部位横断组。结论　在制备视神经损伤SD大鼠模型时，损伤视神经应在鞘内进行，损伤部位距眼球后极　6.0 mm最佳。

关键词: SD大鼠, 视网膜中央动脉, 明胶墨汁, 乳胶

Abstract:

Objective　To provide anatomical basis for establishment of a reliable animal model of optic nerve injury. Method Red latex perfusion technology was used to observe the origin, course, distribution of central retinal artery, and its relationship with the optic nerve in normal SD rats and measurement about several parameters was made on the micrographs recorded using the stereoscopic microscope; Moreover, gelatin-ink perfusion technique was adopted to demonstrate the blood supply of the retina with the optic nerve transected at 2.0 mm and 6.0 mm posterior to the posterior pole of the eye. Result Our study shown the central retinal artery and its branches run with the optic nerve at its course within the optic nerve sheath; the origin of the central retinal artery was located (5.784±0.054) mm posterior to the posterior pole of the eye; the vascular density of the central retinal nerve is highest at the sectional surface of it 6.0 mm posteior to the posterior role of the eye. Conclusion In the preparation of the SD rats model with nerve injury, transection should be made within the sheath, with the best place of the transection being located 6.0 mm posterior to the posterior pole of the eye.

Key words: SD rat, Central retina artery, Gelatin ink, Latex

中图分类号:

R322.91
R774

万炜, 刘政海, 伍校琼, 王晓晟, 罗学港. SD大鼠视网膜中央动脉的应用解剖学研究[J]. 中国临床解剖学杂志, 2013, 31(3): 279-282.

MO Wei, LIU Zheng-Hai, WU Jiao-Qiong, WANG Xiao-Cheng, LUO Hua-Gang. Applied anatomic study about the central retinal artery in SD rats[J]. Chinese Journal Of Clinical Anatomy, 2013, 31(3): 279-282.

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