血管抑素联合丝裂霉素C防止原发性翼状胬肉术后复发的临床疗效观察

中国临床解剖学杂志 ›› 2013, Vol. 31 ›› Issue (2): 225-228.

血管抑素联合丝裂霉素C防止原发性翼状胬肉术后复发的临床疗效观察

许丹丹¹，　刘海俊²，　李燕³，　刘子彬²

1.南方医科大学，广州 510515； 2.解放军第四二一医院，广州 510318；
3.广东省国际旅行卫生保健中心，广州 510635

收稿日期:2012-12-12 发布日期:2013-04-08
通讯作者: 刘海俊，主任医师，硕士生导师，E-mail:233351572@　qq.com E-mail:ophxdd@126.com
作者简介:许丹丹(1986-)，女，在读研究生，住院医师，主要研究方向：眼表疾病
基金资助:
广东省自然科学基金(S2011010000116)

The clinical curative effect of primary pterygium's postoperative recurrence by Angiostatin combined with Mitomycin C

XU Dan-dan¹, LIU Hai-jun², LI Yan³，LIU Zi-bin²

1.Southern Medical University, Guangzhou 510515, China; 2.No. 421 Hospital of Chinese PLA, Guangzhou 510318, China; 3.Guangdong International Travel Healthcare Center, Guangzhou 510635, China

Received:2012-12-12 Published:2013-04-08

摘要/Abstract

摘要：

目的　观察血管抑素（Angiostatin AS）联合丝裂霉素C（Mitomycin MMC）防止原发性翼状胬肉术后复发的临床疗效。方法对365例（369眼）原发性翼状胬肉随机分成3组，分别采用A组行逆行性翼状胬肉切除术联合丝裂霉素（121眼），B组行逆行性翼状胬肉切除术联合血管抑素（122眼），C组行逆行性翼状胬肉切除术联合丝裂霉素及血管抑素（126眼）等方法治疗，随访12～18个月，比较其复发率。结果 3组间差异具有显著性意义（P<0.05），C组复发率（0.8%, 1/126）最低，其次是B组（5.7%, 　7/122），最后是A组（7.4%, 9/121）。结论逆行性翼状胬肉手术联合丝裂霉素C及血管抑制素治疗原发性翼状胬肉，其疗效显著，复发率低，值得推广。

关键词: 血管抑素, 丝裂霉素C, 原发性翼状胬肉, 临床疗效

Abstract:

Objective　To study the clinical curative effect of primary pterygium's postoperative recurrence by Angiostatin combined with Mitomycin C.　 Methods　365 cases (369 eyes) with primary pterygium were divided into three random groups : A group (121 eyes) was treated with retrograde resection combined with M MC; B group (122 eyes) was treated with retrograde resection combined with AS and C group (126 eyes) was treated with retrograde resection combined with AS and MMC. Follow-up of 12～18 months was carried out , the recurrence rate was then compared.　Results　The difference among the 3 groups was significant （P<0.05）. Group C recurrence rate （0.8%, 1/126）was minimum, the next was group B (5.7%, 7/122), and the last was group A (7.4%, 9/121).　Conclusions　The retrograde resection combined with AS and MMC is a distinct effective remedy in treatment of primary pterygium. It can achieve good result reduced the recurrence rate and is , therefore, worth spreading.

Key words: Angiostatin, Mitomycin C, Primary pterygium, Clinical curative effect

中图分类号:

R777.33

许丹丹, 刘海俊, 李燕, 刘子彬. 血管抑素联合丝裂霉素C防止原发性翼状胬肉术后复发的临床疗效观察[J]. 中国临床解剖学杂志, 2013, 31(2): 225-228.

HU Dan-Dan, LIU Hai-Dun, LI Yan, LIU Zi-Ban. The clinical curative effect of primary pterygium's postoperative recurrence by Angiostatin combined with Mitomycin C[J]. Chinese Journal Of Clinical Anatomy, 2013, 31(2): 225-228.

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