改良阴茎海绵体压力测定方法在建立糖尿病性ED大鼠模型中的应用研究

中国临床解剖学杂志 ›› 2013, Vol. 31 ›› Issue (2): 192-195.

改良阴茎海绵体压力测定方法在建立糖尿病性ED大鼠模型中的应用研究

吴子云，　何书华，　张涛，　刘路浩，　韦安阳

南方医科大学南方医院惠侨楼泌尿外科，广州 510515

收稿日期:2012-12-10 发布日期:2013-04-08
通讯作者: 韦安阳，教授，博士生导师，Tel：（020）61642231，E-mail：profway@126.com E-mail:wzy_china@qq.com
作者简介:吴子云（1988-），男，江西赣州人，医学硕士，研究方向：男科学，Tel：13760806572
基金资助:
国家自然科学基金（81170566）

Research for modification of intracavernous pressure monitoring in establishing rat model with diabetic erectile dysfunction

WU Zi-yun, HE Shu-hua, ZHANG Tao, LIU Lu-hao, WEI An-yang

Department of Urology, Medical Center for Overseas Patients, Nanfang Hospital, Southern Medical University, Guangzhou 510515,China

Received:2012-12-10 Published:2013-04-08

摘要/Abstract

摘要：

目的　评价改良阴茎海绵体压力（intracavernous pressure, ICP）测定方法在建立糖尿病性勃起功能障碍（erectile dysfunction, ED）大鼠模型中的应用。方法　将40只8周龄雄性SD大鼠随机分为糖尿病组及正常对照组，检测大鼠ICP及颈动脉压力（arterial pressure, AP），改良法采用带倒刺的穿刺针刺入阴茎脚。结果　在糖尿病组及正常对照组中，与传统方法比较，采用改良阴茎海绵体压力测定方法所测的ICP与AP结果均无统计学意义（P ＞ 0.05），但改良法穿刺针不易脱出，保证了实验顺利进行，成功率大大提高（传统法成功率75%，改良法100%）。结论　改良的带倒刺的穿刺针刺入阴茎脚测定大鼠阴茎海绵体压力具有稳定、准确、方便和不易脱出的特点，对筛选糖尿病性ED大鼠动物模型、评价大鼠阴茎勃起功能具有重要意义。

关键词: 改良, 阴茎海绵体压力, 方法, 勃起功能障碍, 糖尿病

Abstract:

Objective　To evaluate the modified method of intracavernous pressure(ICP) monitoring in establishing rat model with diabetic erectile dysfunction.　Methods　Forty male rats were randomized equally into 2 groups (control group and diabetic group). ICP and arterial pressure (AP) were monitored with the improved method and the traditional method, respectively. The modified method used improved intravenous infusion needle puncture in the crus of penis. Results There was no significant difference in measurement of the ICP and AP between the modified method and the traditional method（P＞0.05）, both in the control group and diabetic group. The modified method used improved intravenous infusion needle puncture in the crus of penis can improve the success rate significantly (the traditional method being 75% and the modified method being 100%).　Conclusion　The modified method of intracavernous pressure monitoring has characteristic of stable、accurate、higher success rate. It is of great significance for establishing rat model with diabetic erectile dysfunction and evaluating rat penile erectile function.

Key words: Modification, Intracavernous pressure, Method, Erectile dysfunction, Diabetic

中图分类号:

R698

吴子云, 何书华, 张涛, 刘路浩, 韦安阳. 改良阴茎海绵体压力测定方法在建立糖尿病性ED大鼠模型中的应用研究[J]. 中国临床解剖学杂志, 2013, 31(2): 192-195.

TUN Zi-Yun, HE Shu-Hua, ZHANG Chao, LIU Lu-Gao, HUI An-Yang. Research for modification of intracavernous pressure monitoring in establishing rat model with diabetic erectile dysfunction[J]. Chinese Journal Of Clinical Anatomy, 2013, 31(2): 192-195.

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