3D-FS-SPGR序列在膝关节软骨病变的临床应用研究
Clinical application of 3D-FS-SPGR sequence on the disease of knee articular cartilage
目的 利用3D-FS-SPGR序列测量各期膝关节OA软骨厚度，探讨OA膝关节软骨厚度与病变进展的关系。 方法 62例OA患者行膝关节MRI检查，用3D-FS-SPGR序列测量不同部位关节软骨的厚度，并与20名对照组膝关节MRI检查结果进行比较。 结果 轻度OA组关节软骨厚度与正常组之间无统计学差异（P＞0.05），而重度OA组大部分软骨区域软骨厚度与正常组有统计学差异（P＜0.05）。软骨厚度的改变可能受到多方面因素的影响，年龄、体重及BMI等与软骨厚度改变之间存在负相关。 结论 关节软骨负重面大部分区域随着OA病情的加重，其软骨厚度变薄，软骨厚度改变可能还受到体重、年龄及性别等因素的影响。
Objective To detect cartilage thickness and pathological progress at various phases of osteoarthritis (OA) happened in articular genus using MR 3D-FS-SPGR sequence. Methods 62 cases of OA were included in this study for detecting articular cartilage thickness by MR 3D-FS-SPGR sequence, followed by MRI scan. 20 young healthy volunteers were taken as controls and performed MRI detection. Results For gentle OA cases, there was no statistical difference of articular cartilage thickness with that in normal volunteers, however, articular cartilage in serious OA cases was significant different from that in the normal volunteers. In addition, multiple factors, such as sex, age, weight and BMI, might affect the thickness of knee articular cartilage. Conclusions By comparing of articular cartilage thickness between OA cases and healthy volunteers, the articular cartilage thickness in a bulk of cartilage weigh-loading surface attenuated gradually, following with the aggregated OA disease. Except for the degree of disease, it might be affected by multiple factors, such as weight, age, sex, and so on.
骨性关节炎 / 膝关节 / 软骨 / 磁共振成像 / 3D-FS-SPGR序列
Osteoarthritis (OA) / Articular genu / Cartilage / Magnetic resonance imaging / 3D-FS-SPGR sequence
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