目的　探讨EDC交联的脱细胞异种（猪）肌腱生物学特性,为其作为肌腱移植材料的应用研究提供依据。　方法　猪肌腱脱细胞后进行EDC改性处理，进行组织形态学、生物力学、体外降解性能、免疫性能和细胞相容性检测，并与新鲜肌腱、深低温冷冻肌腱和单纯脱细胞肌腱进行比较。　结果　EDC改性的脱细胞肌腱免疫原性最低，且力学性能、体外降解特性显著优于单纯脱细胞肌腱，而与新鲜肌腱、冻存肌腱无显著性差异，各组之间的细胞相容性无显著性差异。　结论　EDC改性的脱细胞肌腱具有较低的免疫原性和较好的生物学力学特性，是一种具有潜在应用价值的肌腱支架材料。

Objective  To study the biological properties of 1-ethyl-3-3-dimethyl-aminopropylcarbodiimide hydrochloride（EDC）cross-linking xenogeneic（porcine） acellular  tendon（EPAT） as biological scaffold materials for tendon grafting.   Methods   The fresh porcine tendons were treated with trypsin and Triton X-100 to remove all cell components, then crosslinked with EDC. The features of histomorphology，biomechanics, degradation，immunogenicity and cell biocompatibility were assayed and compared with fresh tendon, freezed tendon and acellular tendon. Results Immunogenicity of EPAT declined significantly, conversely, biomechanics, degradation and cell biocompatibility of EPAT were not statistically significant compared with freezed tendon and acellular tendon. The biocompatibility in vitro had no difference among different treated materials.  Conclusions   EPAT could be the promising tendon graft for its optimal biological properties.