胎儿小脑发育的MRI研究及其意义

刘 菲, 李振平, 刘树伟, 张忠和, 林祥涛, 耿鹤群, 徐君海

中国临床解剖学杂志 ›› 2010, Vol. 28 ›› Issue (2) : 155.

中国临床解剖学杂志 ›› 2010, Vol. 28 ›› Issue (2) : 155.
断层影像解剖

胎儿小脑发育的MRI研究及其意义

  • 刘 菲1, 李振平1, 刘树伟1, 张忠和1, 林祥涛1,2, 耿鹤群1, 徐君海1
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The development of fetal cerebellum assessed by MR images

  • LIU Fei, LI Zhen-ping, LIU Shu-wei, et al.
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摘要

    目的 应用胎儿标本MR图像测量小脑的径线和体积,获得小脑发育指标的正常范围。 方法    87例无中枢神经系统疾病的胎儿标本,胎龄为14~40周,行3.0TMR扫描,使用Amira软件分别测量小脑径线:横径(TCD),前后径(A-PD)、上下径(小脑蚓长度)及小脑体积(CV),并分析它们与胎龄的关系。 结果 小脑横径、前后径、上下径均随胎龄呈直线增长趋势,TCD=0.165FA-1.410(r2=0.929, P<0.05); A-PD=0.091FA-0.717(r2=0.833, P<0.05); (vermis length)=0.108FA-0.832(r2=0.859, P<0.05);小脑体积随胎龄增加呈指数曲线增长,CV=0.034 exp (FA/5.918)(r2=0.915,P<0.05),小脑体积的倍增时间为4.1周。 结论 胎儿标本MR图像可以清晰并准确的显示胎儿小脑大小的发育变化,所得测量结果可为临床宫内胎儿小脑发育状况的诊断与评估提供解剖和影像学依据。

Abstract

Objective To measure the volume and main dimensions of fetal cerebellum with MRI, and obtain the ranges of their normal values.  Methods 87 fetal specimens without CNS diseases aged from 14-40 gestational weeks were scanned under 3.0T MRI. The cerebellar transverse diameter (TCD), anteroposterior diameter (A-PD), vermis length and cerebellar volume were then calculated by Amira software. Lastly the relationship between these values with fetal age(FA) was analyzed statistically.   Results The TCD, A-PD and vermis length increased linearitily following the growth of the fetuses [TCD=0.165FA-1.410; A-PD=0.091FA-0.717; vermis length=0.108FA-0.832]. The relationship between cerebellar volume (in cubic centimeters) and FA (in weeks) was well described by a single exponential function [CV=0.034 exp (FA/5.918)]. The doubling time of CV was about 4.1 weeks.   Conclusions The development of fetal cerebellum could be displayed and quantified by 3.0T MRI, which is valuable for clinical diagnosis and evaluation of fetal development in vivo.

关键词

胎儿 / 小脑 / MR / 标本

Key words

Foetus / Cerebellum / MR / Specimen

引用本文

导出引用
刘 菲, 李振平, 刘树伟, 张忠和, 林祥涛, 耿鹤群, 徐君海. 胎儿小脑发育的MRI研究及其意义[J]. 中国临床解剖学杂志. 2010, 28(2): 155
LIU  Fei, LI Zhen-Beng, LIU Shu-Wei, ZHANG Zhong-He, LIN Xiang-Chao, GENG He-Qun, XU Jun-Hai. The development of fetal cerebellum assessed by MR images[J]. Chinese Journal of Clinical Anatomy. 2010, 28(2): 155
中图分类号:      R323.1    R322.81   

基金

山东省自然科学基金资助项目(Y2006C28)


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