目的  试图优化硫酸钡的血管造影效果，使之能替代有毒的氧化铅。方法  45只SD大鼠，应用不同性状的硫酸钡、不同的载体，制备不同配比的溶液。并调整硫酸钡X线造影参数，进行对比试验。结果  筛选出硫酸钡血管造影术的最佳配方为：硫酸钡27 g,乳胶10 ml，水20 ml，温度20℃，灌注量20～30　ml/300 g。结论  优化后的硫酸钡灌注血管造影成像效果有显著提高，可达到氧化铅血管造影的效果，且因硫酸钡无毒，不失为一种安全有效的血管形态学研究途径。

         Objective  To improve the angiographic images of barium sulfate-latex injection technique and replace toxic lead oxide as the standard contrast medium. Methods  45 SD rats underwent angiography compared with different concentrations and types of latex, and the proportion of barium sulfate to latex, and adjusted radiographic parameters for the injection of barium sulfate. Results  The perfusate was prepared as follows: 10ml of latex was diluted in 20ml of water(20℃), with 27 grams of barium sulfate (used in clinical medicine) added. The average amount of barium sulfate mixture injected was 20-30ml/300g, which provided high quality angiograms. Conclusions  Modified Barium Sulfate-latex technique provides high-quality angiograms. Besides, barium sulfate does no harm to the health of researchers, which makes it a good method for the study of cutaneous artery and perforator flap.