骨脂平衡的调控机制研究进展

doi:10.13418/j.issn.1001-165x.2026.5.17

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中国临床解剖学杂志 ›› 2026, Vol. 44 ›› Issue (5) : 621-624. DOI: 10.13418/j.issn.1001-165x.2026.5.17

综述

骨脂平衡的调控机制研究进展

王唯¹，陈思慧²，李欧¹，姜玉新³，朱锦宇²*

作者信息 +

Research progress on the regulatory mechanism of bone-fat balance

Wang Wei¹, Chen Sihui², Li Ou¹, Jiang Yuxin³, Zhu Jinyu²*

Author information +

文章历史 +

摘要

骨质疏松（osteoporosis, OP）是骨重塑失衡引发的骨骼疾病，而骨脂平衡作为骨髓脂肪组织（Bone Marrow Adipose Tissue, BMAT）与骨量间的动态平衡，是骨重塑正常进行的关键。本文阐述了骨脂平衡多种调控的研究进展，PPAR-γ等信号通路构成调控基础，瘦素、骨钙素等激素与代谢因子通过内分泌、旁分泌途径调节骨髓间充质干细胞分化。同时，氧化应激、铁死亡、衰老及神经系统等多因素也深度参与调控过程，并且多组学技术为调控机制解析提供新技术，新型靶向药物研发向多靶点、精准化演进。BMAT作为关键调控节点，通过复杂机制与上述调控过程双向互作共同推动OP的发生发展，目前骨脂平衡的调控还需深入研究，进而制定更有效的预防和治疗策略，为改善人体骨骼健康提供更多理论依据。

Abstract

Osteoporosis (OP) is a skeletal disease caused by bone remodeling imbalance, where bone-fat balance-defined as the dynamic equilibrium between bone marrow adipose tissue (BMAT) and bone mass is crucial for normal bone remodeling. This article reviews the research progress on various regulatory mechanisms of bone-fat balance, with signaling pathways such as PPAR-γ serving as the regulatory foundation. Hormones and metabolic factors, including leptin and osteocalcin, regulate the differentiation of bone marrow mesenchymal stem cells through endocrine and paracrine pathways. Additionally, multiple factors such as oxidative stress, ferroptosis, aging, and the nervous system are deeply involved in this regulatory process. Multi-omics technologies provide novel approaches for elucidating regulatory mechanisms, while the development of novel targeted drugs is evolving toward multi-target and precision therapies. As a key regulatory node, BMAT interacts bidirectionally with the aforementioned regulatory processes through complex mechanisms, collectively driving the onset and progression of OP. Further research is needed to elucidate the regulation of bone-fat balance, thereby formulating more effective prevention and treatment strategies and providing theoretical foundations for improving human skeletal health.

导出引用

王唯, 陈思慧, 李欧, 姜玉新, 朱锦宇. 骨脂平衡的调控机制研究进展[J]. 中国临床解剖学杂志. 2026, 44(5): 621-624 https://doi.org/10.13418/j.issn.1001-165x.2026.5.17

Wang Wei, Chen Sihui, Li Ou, Jiang Yuxin, Zhu Jinyu. Research progress on the regulatory mechanism of bone-fat balance[J]. Chinese Journal of Clinical Anatomy. 2026, 44(5): 621-624 https://doi.org/10.13418/j.issn.1001-165x.2026.5.17

中图分类号： R681.1

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