针灸对保胆取石术后患者胆囊收缩功能的疗效观察

doi:10.13418/j.issn.1001-165x.2025.5.18

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中国临床解剖学杂志 ›› 2025, Vol. 43 ›› Issue (5) : 612-617. DOI: 10.13418/j.issn.1001-165x.2025.5.18

临床研究

针灸对保胆取石术后患者胆囊收缩功能的疗效观察

王三贵^1,2，陈利芳¹，王海峰¹，严柏文³，王芷⁴，王妮¹，李嘉豪¹，李云⁵，王全磊^1,2,4*

作者信息 +

Observation on the therapeutic effect of acupuncture on the gallbladder contraction function of patients after gallbladder-preserving cholecystolithotomy

Wang Sangui^1,2, Chen Lifang¹, Wang Haifeng¹, Yan Bowen³, Wang Zhi⁴, Wang Ni¹, Li Jiahao¹, Li Yun⁵, Wang Quanlei^1,2,4*

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摘要

目的探讨针灸对保胆取石（gallbladder-preserving cholecystolithotomy，GPC）术后患者胆囊收缩功能的影响。方法本研究共纳入70例保胆取石 GPC患者，分为针灸组（n=41）和非穴位组（假针灸组，n=29）。在针灸组中，对阳陵泉（GB34）、胆囊穴（EX-LE6）、期门（LR14）、足三里（ST36）穴位进行针灸治疗；而在假针灸组中，在相应穴位周围2寸处，细针接触而不插入皮肤。两组均每日进行一次针灸治疗，连续七天。使用彩色多普勒超声扫描仪，在针灸前及针灸后1、3、6月检测胆囊排空指数（gallbladder ejection fraction，GBEF）。在针灸刺激后1月，通过酶联免疫吸附测定法检测血清胆囊收缩素A受体（cholecystokinin A receptor，CCKAR）和胃泌素（gastrin）水平。结果与基线相比，针灸组和假针灸组的GBEF明显增加。与假针灸组相比，针灸组在 GPC术后1月和3月时GBEF相对更高，两组之间具有显著性差异（P<0.001）；而在6月时，针灸组的GBEF与假针灸组的GBEF无显著差异。血清CCKAR增加，但不显著（P>0.05），而胃泌素在针灸组中显著减少（P<0.01）。结论针灸治疗可有效促进GBEF，其可能通过CCKAR/胃泌素信号进行调控。

Abstract

Objective To investigate the effect of acupuncture on the gallbladder contraction function in patient after gallbladder-preserving cholecystolithotomy (GPC). Methods Total seventy cases of GPC patients, including acupuncture group (n=41) and non-acupoint (sham-acupuncture) group (n=29) were enrolled in this study. In acupuncture group, acupuncture was applied to Yanglingquan (GB34), Dannangxue (EX-LE6), Qimen (LR14), Zusanli (ST36), while the filiform needle was touched but not inserted skin 2 cun around the corresponding acupoints for the sham-acupuncture group, and the needles were retained for 30 min. Acupuncture was preformed once daily and total for consecutive 7 days in these two groups. A color Doppler ultrasound scanner was used to detect the gallbladder ejection fraction (GBEF) before and 1, 3, 6 months after acupuncture operation. Serum cholecystokinin-A receptor (CCKAR) and gastrin were detected by enzyme-linked immunosorbent assay at 1 months after acupuncture stimulation. Results The GBEF were markedly increased compared to the baseline. Compare to sham-acupuncture group, the GBEF were significantly higher at 1 month and 3 months (P<0.001), while that were similar at 6 months in acupuncture group. Serum CCKAR were increased but not significant (P>0.05), whereas gastrin significantly decreased in the acupuncture group (P<0.01). Conclusions Acupuncture can effectively promote GBEF which might be regulated though CCKAR/gastrin signals.

导出引用

王三贵, 陈利芳, 王海峰, 严柏文, 王芷, 王妮, 李嘉豪, 李云, 王全磊. 针灸对保胆取石术后患者胆囊收缩功能的疗效观察[J]. 中国临床解剖学杂志. 2025, 43(5): 612-617 https://doi.org/10.13418/j.issn.1001-165x.2025.5.18

Wang Sangui, Chen Lifang, Wang Haifeng, Yan Bowen, Wang Zhi, Wang Ni, Li Jiahao, Li Yun, Wang Quanlei. Observation on the therapeutic effect of acupuncture on the gallbladder contraction function of patients after gallbladder-preserving cholecystolithotomy[J]. Chinese Journal of Clinical Anatomy. 2025, 43(5): 612-617 https://doi.org/10.13418/j.issn.1001-165x.2025.5.18

中图分类号： R575.6 R246

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