[1] Baughman JM, Perocchi F, Girgis HS, et al. Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter[J]. Nature, 2011, 476(7360): 341-345. DOI: 10.1038/nature10234.
[2] Walters GC, Usachev YM. Mitochondrial calcium cycling in neuronal function and neurodegeneration[J]. Front Cell Dev Biol, 2023, 11: 1094356. DOI: 10.3389/fcell.2023.1094356.
[3] Garbincius JF, Elrod JW. Mitochondrial calcium exchange in physiology and disease[J]. Physiol Rev, 2022, 102(2): 893-992. DOI: 10.1152/physrev.00041.2020.
[4] Sancak Y, Markhard AL, Kitami T, et al. EMRE is an essential component of the mitochondrial calcium uniporter complex[J]. Science, 2013, 342(6164): 1379-1382. DOI: 10.1126/science.1242993.
[5] Watanabe A, Maeda K, Nara A, et al. Quantitative analysis of mitochondrial calcium uniporter (MCU) and essential MCU regulator (EMRE) in mitochondria from mouse tissues and HeLa cells[J]. FEBS Open Bio, 2022, 12(4): 811-826. DOI: 10.1002/2211-5463.13371.
[6] MacEwen MJ, Markhard AL, Bozbeyoglu M, et al. Evolutionary divergence reveals the molecular basis of EMRE dependence of the human MCU[J]. Life Sci Alliance, 2020, 3(10): e202000718. DOI: 10.26508/lsa.202000718.
[7] Perocchi F, Gohil VM, Girgis HS, et al. MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake[J]. Nature, 2010, 467(7313): 291-296. DOI: 10.1038/nature09358.
[8] Csordás G,Golenár T,Seifert EL,et al.MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter[J]. Cell Metab,2013, 17(6): 976-987. DOI: 10.1016/j.cmet. 2013. 04.020.
[9] Ghosh S, Basu Ball W, Madaris TR, et al. An essential role for cardiolipin in the stability and function of the mitochondrial calcium uniporter[J]. Proc Natl Acad Sci U S A, 2020, 117(28): 16383-16390. DOI: 10.1073/pnas.2000640117.
[10]Jin M, Wang J, Ji X, et al. MCUR1 facilitates epithelial-mesenchymal transition and metastasis via the mitochondrial calcium dependent ROS/Nrf2/Notch pathway in hepatocellular carcinoma[J]. J Exp Clin Cancer Res, 2019, 38(1): 136. DOI: 10.1186/s13046-019-1135-x.
[11]Lambert JP, Luongo TS, Tomar D, et al. MCUB regulates the molecular composition of the mitochondrial calcium uniporter channel to limit mitochondrial calcium overload during stress[J]. Circulation, 2019, 140(21): 17201733. DOI: 10.1161/circulationaha.118.037968.
[12]蔡红艳, 乔晶, 陈思茹, 等. 海马神经元敲低MCU改善阿尔茨海默病小鼠学习记忆功能障碍[J]. 生理学报, 2022, 74(5): 715-725. DOI: 10.13294/j.aps.2022.0081.
[13]Jiang C, Shen J, Wang C, et al. Mechanism of aconitine mediated neuronal apoptosis induced by mitochondrial calcium overload caused by MCU[J]. Toxicol lett,2023, 384: 86-95. DOI: 10.1016/j.toxlet. 2023.07.014.
[14]Chitturi J, Santhakumar V, Kannurpatti SS. Beneficial effects of kaempferol after developmental traumatic brain injury is through protection of mitochondrial function, oxidative metabolism, and neural viability[J]. J Neurotrauma, 2019, 36(8): 1264-1278. DOI: 10.1089/neu.2018.6100.
[15]Nichols M, Pavlov EV, Robertson GS. Tamoxifen-induced knockdown of the mitochondrial calcium uniporter in Thy1-expressing neurons protects mice from hypoxic/ischemic brain injury[J]. Cell Death Dis, 2018, 9(6): 606. DOI: 10.1038/s41419-018-0607-9.
[16]Woods JJ, Novorolsky RJ, Bigham NP, et al. Dinuclear nitrido-bridged osmium complexes inhibit the mitochondrial calcium uniporter and protect cortical neurons against lethal oxygen-glucose deprivation[J]. RSC Chem Biol, 2023, 4(1): 84-93. DOI: 10.1039/d2cb00189f.
[17]Manikandan M, Walker S, Deshmukh AR, et al. Mitochondrial calcium uniporter is essential for hearing and hair cell preservation in congenic FVB/NJ mice[J]. Sci Rep, 2021, 11(1): 9660. DOI: 10.1038/s41598-021-88841-0.
[18]Tadić V, Adam A, Goldhammer N, et al. Investigation of mitochondrial calcium uniporter role in embryonic and adult motor neurons from G93A(hSOD1) mice[J]. Neurobiol Aging, 2019, 75: 209-222. DOI: 10.1016/j.neurobiolaging. 2018.11.019.
[19]Fields RD, Araque A, Johansen-Berg H, et al. Glial biology in learning and cognition[J]. Neuroscientist, 2014, 20(5): 426-431. DOI: 10.1177/1073858413504465.
[20]Miao Y, Sun X, Gao G, et al. Evaluation of (-)-epigallocatechin-3-gallate (EGCG)-induced cytotoxicity on astrocytes: a potential mechanism of calcium overloading-induced mitochondrial dysfunction[J]. Toxicol In Vitro, 2019,61: 104592. DOI: 10.1016/j.tiv. 2019. 104592.
[21]Serrat R, Covelo A, Kouskoff V, et al. Astroglial ER-mitochondria calcium transfer mediates endocannabinoid-dependent synaptic integration[J]. Cell Rep,2021,37(12): 110133. DOI: 10.1016/j.celrep. 2021. 110133.
[22]Holman SP, Lobo AS, Novorolsky RJ, et al. Neuronal mitochondrial calcium uniporter deficiency exacerbates axonal injury and suppresses remyelination in mice subjected to experimental autoimmune encephalomyelitis[J]. Exp Neurol, 2020, 333: 113430. DOI: 10.1016/j.expneurol.2020.113430.
[23]Sharma GN, Gupta G, Sharma P. A comprehensive review of free radicals, antioxidants, and their relationship with human ailments[J]. Crit Rev Eukaryot Gene Expr, 2018, 28(2): 139-154. DOI: 10.1615/Crit Rev Eukaryot Gene Expr. 2018022258.
[24]Liu ZJ, Zhao W, Lei HY, et al. High glucose enhances bupivacaine-induced neurotoxicity via MCU-mediated oxidative stress in SH-SY5Y cells[J]. Oxid Med Cell Longev, 2019, 2019: 7192798. DOI: 10.1155/2019/7192798.
[25]Fei M, Zhang L, Wang H, et al. Inhibition of cathepsin S induces mitochondrial apoptosis in glioblastoma cell lines through mitochondrial stress and autophagosome accumulation[J]. Front Oncol, 2020, 10: 516746. DOI: 10.3389/fonc. 2020.516746.
[26]Chen X, Wu G, Zhang Z, et al. Neurotoxicity of Mn(3)O(4) nanoparticles: Apoptosis and dopaminergic neurons damage pathway[J]. Ecotoxicol Environ Saf, 2020,188: 109909. DOI: 10.1016/j.ecoenv. 2019.109909.
[27]Cai H, Qiao J, Chen S, et al. MCU knockdown in hippocampal neurons improves memory performance of an Alzheimer's disease mouse model[J]. Acta Biochim Biophys Sin (Shanghai), 2022, 54(10): 1528-1539. DOI: 10.3724/abbs.2022138.
[28]Yu M, Yang J, Gao X, et al. Lanthanum chloride impairs spatial learning and memory by inducing [Ca(2+)](m) overload, mitochondrial fission-fusion disorder and excessive mitophagy in hippocampal nerve cells of rats[J]. Metallomics, 2020, 12(4): 592-606. DOI: 10.1039/c9mt00291j.
[29]Zhou G, Ye Q, Xu Y, et al. Mitochondrial calcium uptake 3 mitigates cerebral amyloid angiopathy-related neuronal death and glial inflammation by reducing mitochondrial dysfunction[J]. Int Immuno pharmacol, 2023, 117: 109614. DOI: 10.1016/j.intimp.2022.109614.
[30]Duan W, Liu C, Zhou J, et al. Upregulation of mitochondrial calcium uniporter contributes to paraquat-induced neuropathology linked to Parkinson's disease via imbalanced OPA1 processing[J]. J Hazard Mater, 2023, 453. 131369. DOI: 10.1016/j.jhazmat.2023.131369.
[31]Nourse JB Jr, Harshefi G, Marom A, et al. Conserved nicotine-activated neuroprotective pathways involve mitochondrial stress[J]. iScience, 2021, 24(3): 102140. DOI: 10.1016/j.isci.2021.102140.
[32]Naumova N, Šachl R. Regulation of cell death by mitochondrial transport systems of calcium and Bcl-2 proteins[J]. Membranes (Basel), 2020, 10(10): 299. DOI: 10.3390/membranes10100299.
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