青少年海马亚区体积的侧别差异及性别差异

doi:10.13418/j.issn.1001-165x.2024.4.02

摘要/Abstract

摘要： 目的　对青少年时期双侧海马进行精细的亚区划分并统计各亚区体积的侧别差异和性别差异，为海马的功能和相关精神疾病研究提供解剖学依据。方法　收集101例健康青少年3.0T脑磁共振成像。利用FreeSurfer软件进行全脑和双侧海马的亚区分割，获取颅内体积和各亚区体积。利用Cendes法结合颅内体积对海马各亚区体积标准化，最后进行侧别差异和性别差异的统计学分析。结果　使用Cendes法标准化后，HBT（head/body/tail）协议下海马头、海马体和整体体积均右侧>左侧。FS60协议下海马尾、下托等体积无侧别差异；旁下托、前下托体积左侧>右侧，CA1、CA3、海马伞等体积右侧>左侧。HBT协议下双侧海马各亚区体积均女性>男性；FS60协议下左侧下托、CA4，右侧下托、CA1、海马尾等亚区体积均存在女性>男性。结论　青少年海马不同亚区体积具有不同的性别差异和侧别差异性，体现了此时期海马的异质性发育状态，为揭示大脑功能偏侧化的形成和相关精神疾病机制提供了基础。

关键词: 海马亚区, 　青少年, 　磁共振成像, 　侧别差异, 　性别差异

Abstract: Objective To make a detailed subdivision of the hippocampus in adolescents and to analyze the lateralization and sex differences in the volume of each subregion, so as to provide anatomical basis for the study of hippocampal function and related psychiatric diseases. Methods A total of 101 healthy adolescent subjects were collected for 3.0T brain magnetic resonance imaging. After whole-brain segmentation and subregion segmentation of bilateral hippocampus by using FreeSurfer software, intracranial volume and each hippocampal subregion volume were obtained. The volumes of hippocampal subregions were standardized by intracranial volume using Cendes methods. Finally, the lateralization and sex differences of hippocampal subregion volumes after standardization were statistically analyzed. Results Freesurfer software showed clear and good effect in automatic segmentation of hippocampal subregions. In terms of literalization, the HBT（head/body/tail) protocol showed that, except for the hippocampus tail, there were literalization in the volume of the hippocampus head, body and the whole hippocampus, right(R)>left(L). In FS60, there was no literalization in hippocampal tail, hippocampal fissure and subiculum; other subregions had literalization, the volume of CA1, CA3, CA4, GC-ML-DG, molecular layer, HATA, fimbria was R>L, while parasubiculum and presubiculum was L>R. In terms of sex difference, after data standardized by the Cendes method, there was sex difference in the volume of each part on the both sides of the HBT, and female (F)>male (M). For FS60, there was sex difference in parasubiculum, presubiculum, subiculum, CA4, GC-ML-DG, molecular layer, HATA, and hippocampal tail, F>M. Conclusions The volumes of different hippocampal subregions in adolescents have different lateralization and sex differences properties, reflecting the heterogeneous structural characteristics of the hippocampus in this period. This study provides basis for the study of the formation of functional lateralization of the brain and related clinical psychiatric disorders.

Key words: Hippocampal subregions, 　Adolescent, 　Magnetic resonance imaging, 　Lateralization, 　Sex differences

中图分类号:

R445.2

刘宇宁, 滕野, 唐倩, 娄云霞, 王宇, 汤煜春, 刘树伟. 青少年海马亚区体积的侧别差异及性别差异[J]. 中国临床解剖学杂志, 2024, 42(4): 364-371.

Liu Yuning, Teng Ye, Tang Qian, Lou Yunxia, Wang Yu, Tang Yuchun, Liu Shuwei. Lateralization and sex differences of hippocampal subregions volume in adolescents[J]. Chinese Journal of Clinical Anatomy, 2024, 42(4): 364-371.

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