circRNA翻译多肽应用及工程化制备的研究进展

doi:10.13418/j.issn.1001-165x.2024.3.21

中国临床解剖学杂志 ›› 2024, Vol. 42 ›› Issue (3): 356-358.doi: 10.13418/j.issn.1001-165x.2024.3.21

circRNA翻译多肽应用及工程化制备的研究进展

杜坤朔^1,2，杨天一^1,3，贾淑惠^1,2，王芳琳¹，范军¹*

中国医科大学 1.智能医学学院组织工程学教研室， 2.护理学院， 3.临床一系，沈阳 110122

收稿日期:2022-11-14 出版日期:2024-05-25 发布日期:2024-07-01
基金资助:
国家级大学生创新创业项目（202210159022），辽宁省“兴辽英才”计划（3111220002）

The research progress on the application and engineering approaches of circRNA encoded ploypeptides

Du Kunshuo^{1, 2}, Yang Tianyi^{1, 3}, Jia Shuhui^{1, 2}, Wang Fanglin¹, Fan Jun¹*

1. Department of Tissue Engineering, College of Basic Medical Sciences, China Medical University, Shenyang 110122，China; 2.Nursing College, China Medical University, Shenyang 110122，China; 3. Department I of Clinical Medicine, China Medical University, Shenyang 110001，China

Received:2022-11-14 Online:2024-05-25 Published:2024-07-01
About author:杜坤朔(2001-)，本科在读，研究方向：护理学，E-mail: 1453661807@qq.com

摘要/Abstract

关键词: circRNA, , , circRNA翻译, , , 工程化

Key words: circRNA, , , , circRNA translation, , , , Engineering

中图分类号:

杜坤朔, 杨天一, 贾淑惠, 王芳琳, 范军. circRNA翻译多肽应用及工程化制备的研究进展[J]. 中国临床解剖学杂志, 2024, 42(3): 356-358.

Du Kunshuo, Yang Tianyi, Jia Shuhui, Wang Fanglin, Fan Jun. The research progress on the application and engineering approaches of circRNA encoded ploypeptides[J]. Chinese Journal of Clinical Anatomy, 2024, 42(3): 356-358.

参考文献

[1] Kristensen LS, Jakobsen T, Hager H, et al. The emerging roles of circRNAs in cancer and oncology[J]. Nat Rev Clin Oncol, 2022, 19(3): 188-206. DOI: 10.1038/s41571-021-00585-y.
[2] Long F, Lin Z, Li L, et al. Comprehensive landscape and future perspectives of circular RNAs in colorectal cancer[J]. Mol Cancer, 2021, 20(1): 26. DOI: 10.1186/s12943-021-01318-6.
[3] Lee AS, Kranzusch PJ, Doudna JA, et al. eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation[J]. Nature, 2016, 536(7614): 96-99. DOI: 10.1038/nature18954.
[4] Liberman N, Gandin V, Svitkin YV, et al. DAP5 associates with eIF2beta and eIF4AI to promote Internal Ribosome Entry Site driven translation[J]. Nucleic Acids Res,2015,43(7):3764-3775. DOI: 10.1093/ nar/gkv205.
[5] Wang Y, Wu C, Du Y, et al. Expanding uncapped translation and emerging function of circular RNA in carcinomas and noncarcinomas[J]. Mol Cancer, 2022, 21(1): 13. DOI: 10.1186/s12943-021-01484-7.
[6] Ali MM, Li F, Zhang Z, et al. Rolling circle amplification: a versatile tool for chemical biology, materials science and medicine[J]. Chem Soc Rev, 2014, 43(10): 3324-3341. DOI: 10.1039/c3cs60439j.
[7] Warminski M, Kowalska J, Jemielity J. Solid-phase synthesis of RNA 5'-azides and their application for labeling, ligation, and cyclization via click chemistry[J]. Curr Protoc Nucleic Acid Chem, 2020, 82(1): e112. DOI: 10.1002/cpnc.112.
[8] Tang X, Guo M, Ding P, et al. BUB1B and circBUB1B_544aa aggravate multiple myeloma malignancy through evoking chromosomal instability[J]. Signal Transduct Target Ther, 2021, 6(1): 361. DOI: 10.1038/s41392-021-00746-6.
[9] Gao X, Xia X, Li F, et al. Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR-STAT3 signalling[J]. Nat Cell Biol, 2021, 23(3): 278-291. DOI: 10.1038/s41556-021-00639-4.
[10]Lu Y, Li Z, Lin C, et al. Translation role of circRNAs in cancers[J]. J Clin Lab Anal, 2021, 35(7): e23866. DOI: 10.1002/jcla.23866.
[11]Kim D, Han S, Ji Y, et al. Multimeric RNAs for efficient RNA-based therapeutics and vaccines[J]. J Control Release, 2022, 345: 770-785. DOI: 10.1016/j.jconrel.2022.03.052.
[12]Kristensen LS, Andersen MS, Stagsted LVW, et al. The biogenesis, biology and characterization of circular RNAs[J]. Nat Rev Genet, 2019, 20(11): 675-691. DOI: 10.1038/s41576-019-0158-7.
[13]Li H, Peng K, Yang K, et al. Circular RNA cancer vaccines drive immunity in hard-to-treat malignancies[J]. Theranostics, 2022, 12(14): 6422-6436. DOI: 10.7150/thno.77350.
[14]Qu L, Yi Z, Shen Y, et al. Circular RNA vaccines against SARS-CoV-2 and emerging variants[J]. Cell, 2022, 185(10): 1728e16-1744e16. DOI: 10.1016/j.cell.2022.03.044.
[15]Wang T, Liu Z, She Y, et al. A novel protein encoded by circASK1 ameliorates gefitinib resistance in lung adenocarcinoma by competitively activating ASK1-dependent apoptosis[J]. Cancer Lett, 2021, 520: 321-331. DOI: 10.1016/j.canlet.2021.08.007.
[16]Suzuki H, Zuo Y, Wang J, et al. Characterization of RNase R-digested cellular RNA source that consists of lariat and circular RNAs from pre-mRNA splicing[J]. Nucleic Acids Res, 2006, 34(8): e63. DOI: 10.1093/nar/gkl151.
[17]Xu Z, Li P, Fan L, et al. The potential role of circRNA in tumor immunity regulation and immunotherapy[J]. Front Immunol, 2018, 9: 9. DOI: 10.3389/fimmu.2018.00009.
[18]Liu X, Zhang Y, Zhou S, et al. Circular RNA: An emerging frontier in RNA therapeutic targets, RNA therapeutics, and mRNA vaccines[J]. J Control Release, 2022, 348: 84-94. DOI: 10.1016/j.jconrel.2022.05.043.
[19]Liang D, Wilusz JE. Short intronic repeat sequences facilitate circular RNA production[J]. Genes Dev, 2014, 28(20): 2233-2247. DOI: 10.1101/gad.251926.114.
[20]Conn SJ, Pillman KA, Toubia J, et al. The RNA binding protein quaking regulates formation of circRNAs[J]. Cell, 2015, 160(6): 1125-1134. DOI: 10.1016/j.cell.2015.02.014.
[21]Qi Y, Han W, Chen D, et al. Engineering circular RNA regulators to specifically promote circular RNA production[J]. Theranostics, 2021, 11(15): 7322-7336. DOI: 10.7150/thno.56990.
[22]Wesselhoeft RA, Kowalski PS, Anderson DG. Engineering circular RNA for potent and stable translation in eukaryotic cells[J]. Nat Commun, 2018, 9(1): 2629. DOI: 10.1038/s41467-018-05096-6.
[23]Wesselhoeft RA, Kowalski PS, Parker-Hale FC, et al. RNA circularization diminishes immunogenicity and can extend translation duration in vivo[J]. Mol Cell, 2019, 74(3): 508e4-520e4. DOI: 10.1016/j.molcel.2019.02.015.
[24]Liu CX, Chen LL. Circular RNAs: characterization, cellular roles, and applications[J]. Cell, 2022, 185(12): 2016-2034. DOI: 10.1016/j.cell.2022.04.021.
[25]Chen R, Wang SK, Belk JA, et al. Engineering circular RNA for enhanced protein production[J]. Nat Biotechnol, 2023, 41(2): 262-272. DOI: 10.1038/s41587-022-01393-0.

circRNA翻译多肽应用及工程化制备的研究进展

The research progress on the application and engineering approaches of circRNA encoded ploypeptides

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

Metrics

本文评价

推荐阅读 0

[1]	李海艳, 刘英东, 宋东帅, 杨志鹏, 杜心如. 副神经和迷走神经、颈神经根交通支的形态学观察及临床意义[J]. 中国临床解剖学杂志, 2024, 42(3): 241-245.
[2]	孙克, 周广文, 蒋智烨, 王洪岗. 横突根部入路经皮椎弓根螺钉的解剖基础研究[J]. 中国临床解剖学杂志, 2024, 42(3): 246-250.
[3]	马仁财, 马向阳, 邹小宝, 付索超, 邓琛府, 陈钧麟, 陈泽星. 新型枢椎棘突椎板螺钉固定的影像解剖学测量研究[J]. 中国临床解剖学杂志, 2024, 42(3): 251-258.
[4]	赖文华, 毛隆昆, 王诗雨, 李奕宣, 刘瑞平, 徐达政, 李明哲, 周丽华. 华南地区国人成人腹腔干分型变异的临床应用研究[J]. 中国临床解剖学杂志, 2024, 42(3): 259-264.
[5]	李云伦, 许逸舟, 蔡家乐, 许淑怡, 张家琪, 傅兰雅, 马心蕊, 何叶, 王祥海, 郭家松. 氯膦酸盐脂质体通过消耗巨噬细胞延缓周围神经损伤后功能性修复的实验研究[J]. 中国临床解剖学杂志, 2024, 42(3): 265-269.
[6]	阙松年, 涂经典, 韩尚峰, 熊航, 宋海旺, 黄涛. 当归多糖调控肠道菌群对脑缺血再灌注小鼠的影响[J]. 中国临床解剖学杂志, 2024, 42(3): 270-277.
[7]	杨丽芳, 于春泽, 张先俊, 吴春云, 于建云, 杨力. 大麻二酚对大鼠多重脑震荡炎症反应的抑制作用[J]. 中国临床解剖学杂志, 2024, 42(3): 278-283.
[8]	荆幸, 施进兴, 徐丹, 庄跃宏, 谢昀, 王海. 法舒地尔促进大鼠坐骨神经横断伤后的轴突与髓鞘再生及功能恢复[J]. 中国临床解剖学杂志, 2024, 42(3): 284-292.
[9]	张必欢, 蔡兴博, 王斌, 张悦, 徐永清. 个性化3D打印钛合金舟骨部分置换术后有限元模型的建立及生物力学分析[J]. 中国临床解剖学杂志, 2024, 42(3): 293-303.
[10]	齐保闯, 蔡兴博, 宋慕国, 孟晨, 罗欢, 李川, 徐永清. 镍钛记忆合金腕骨四角融合器应用于腕塌陷临床疗效：9~10年随访[J]. 中国临床解剖学杂志, 2024, 42(3): 304-309.
[11]	刘伟湘, 吴宇鹏, 夏超, 龚泳豪, 高义强, 姚女兆. 单侧双通道内镜技术治疗后路腰椎融合术后邻椎病的短期临床研究[J]. 中国临床解剖学杂志, 2024, 42(3): 310-315.
[12]	孙晟轩, 谢晔, 沈光思, 周海斌. 关节镜下 “Chinese way” 治疗老年肩关节脱位合并巨大肩袖撕裂的临床疗效[J]. 中国临床解剖学杂志, 2024, 42(3): 316-321.
[13]	邹洋, 刘佳龙, 金一怡, 李宁磊, 孙景波, 刘晓珑. 喉返神经全程显露三步法于经胸前入路腔镜甲状腺手术的应用[J]. 中国临床解剖学杂志, 2024, 42(3): 322-325.
[14]	胡浩, 周利华, 吕国义. 软骨母细胞瘤和原发性动脉瘤样骨囊肿CT三维重建对比分析[J]. 中国临床解剖学杂志, 2024, 42(3): 326-330.
[15]	王霞, 李家意, 卢惠芬, 崔海燕. 2例吡非尼酮治疗新型冠状病毒肺炎后肺纤维化的疗效分析[J]. 中国临床解剖学杂志, 2024, 42(3): 331-335.