目的 测量大骨节病（Kashin-Beck disease，KBD）患者下颈椎椎体的X线参数，明确KBD对下颈椎椎体发育的影响。 方法 分别对62例KBD患者（KBD组）及67例正常人（对照组）行颈椎侧位X线片检查，观察颈椎椎体的影像学特征，测量两组C3~7椎体前缘、中份及后缘高及前后径，并进行统计学分析。 结果 KBD患者下颈椎椎体上、下面凹凸不平，终板凹陷、硬化。颈C3~7椎体前、后缘高大于中份高，椎体前、后缘高无统计学差异（P>0.05）；KBD组男性C4~6和女性C4~7的椎体中份高小于前、后缘，差异有统计学意义（P<0.05）。对照组男性C4~7及女性C3~7椎体中间高均高于KBD组，差异有统计学意义（P<0.05）。KBD患者男女组间前后径有统计学差异（P<0.05）；对照组男女前后径较KBD组大，差异无统计学意义（P>0.05）。 结论 KBD可引起终板软骨凹陷、不平及硬化，导致颈椎中间高度降低，但对颈椎前后径无明显影响。
Abstract
Objective To measure the X-ray related parameters of lower cervical vertebral body in elderly patients with Kashin-beck disease (KBD), so as to clarify the influence of KBD on the development of lower cervical vertebral body. Methods Sixty-two patients with KBD (KBD group) and sixty-seven healthy people (control group) were treated with lateral cervical radiographs to observe the imaging manifestations of the lower cervical vertebral body. The anterior, middle and posterior heights of the vertebral body and anterior-posterior diameters from C3 to C7 in neutral position were measured and statistical analysis was performed. Results The results of this study showed that the superior and inferior margins of the vertebral endplate were uneven, depressed and sclerosis in some KBD patients. The heights of anterior and posterior margins of vertebral body were higher than that of the middle margin, and there was no significant difference between the height of anterior and posterior margins (P>0.05). In the KBD group, the median heights of C4-6 in males and C4-7 in females were smaller than that of anterior and posterior margin, and the difference was statistically significant (P<0.05). The median heights of C4-7 in males and C3-7 in females in the control group were higher than that in the KBD group, with statistically significant difference(P<0.05). There were significant differences in anterior-posterior diameters between male and female groups in the KBD patients (P<0.05). The anterior -posterior diameters of males and females in the control group were larger than those in the KBD group, but there was no statistical difference (P>0.05). Conclusions KBD can cause the depression, uneven and sclerosis of endplate cartilage, lead to the reduction of the middle height of cervical vertebral body, but do not affect the development of anterior -posterior diameters of the vertebral body.
关键词
大骨节病； /
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椎体高度； /
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终板软骨； /
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颈椎； /
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影像学形态
Key words
Kashin-Beck disease； /
Vertebral heights； /
Endplate cartilage； /
Cervical vertebrae /
Radiographic morphology
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基金
陕西省自然科学基础研究计划项目（2019JM-517）；陕西省人民医院科技发展孵化基金（2019YXQ-10）；陕西省重点研发计划-社会发展领域（2018ZDXM-SF-054）
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