Objective To investigate the plain scan and multi-phase enhancement features of renal chromophobe cell carcinoma by multi-detector spiral computed tomography (MDCT). Methods Clinical data and MDCT signs of 67 cases (68 lesions) of renal chromophobe cell carcinoma were retrospectively analyzed. They were divided into two groups according to the tumor size (group A with the maximum diameter ≤4 cm and group B with the maximum diameter of >4 cm). The MDCT characteristics of the mass in the two groups were compared. The ratio (La0, La1, Lv1, Lp1) of the CT value of the solid part of the mass in plain scan, renal cortex stage, parenchymal stage and renal pelvis stage to the CT value of the ipsilateral adjacent renal cortex (La0, La1, Lv1, Lp1) were calculated and graded, and the enhancement mode of the mass was analyzed and statistically analyzed. Results There were significant differences in the percentage of calcification, central scar and small cortical vascular signs in the tumor and the percentage of compression of calices, pelvis and portal vessels by the tumor between group A and B (all P<0.05).There were significant differences among La1, Lv1 and Lp1 in the solid part of 68 masses (P<0.05). The enhancement peak value was the most in the dermato-pith junction or parenchymal phase, accounting for 61.76% (42/68), of which followed by the cortical phase, accounting for 33.82% (23/68), and there were significant differences in the dermato-pith junction or parenchymal phase and the cortical phase (P<0.05). Conclusions The partial MDCT features of renal chromophobe cell carcinoma are related to the size of the tumor, and the enhancement methods are varied. Careful observation of plain scan features and multistage enhancement features of the tumor is helpful for preoperative diagnosis and differential diagnosis.
Key words
Multi-phase enhanced scanning /
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Chromophobe cell carcinoma /
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Computed tomography (CT)
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References
[1] Moch H, Cubilla AL, Humphrey PA, et al. The 2016 WHO classification of tumours of the urinary system and male genital organs- part a: renal, penile, and testicular tumours[J]. Eur Urol, 2016, 70(1): 93-105. DOI: 10.1016/j.eururo.2016.02.029.
[2] Jiang HM, Wei JH, Zhang ZL, et al. Does chromophobe renal cell carcinoma have better survival than clear cell renal cell carcinoma? A clinical-based cohort study and meta-analysis[J]. Int Urol Nephrol, 2016 ,48(2): 191-199. DOI: 10.1007/s11255-015-1161-3.
[3] Raman SP, Johnson PT, Allaf ME, et al. Chromophobe renal cell carcinoma: multiphase MDCT enhancement patterns and morphologic features[J]. AJR Am J Roentgenol, 2013, 201(6): 1268-1276. DOI: 10.2214/AJR.13.10813.
[4] 方权, 徐鹏举, 韩太林. 肾嫌色细胞癌CT征象分析[J]. 医学影像学杂志, 2014, 24(5): 886-890. CNKI: SUN:XYXZ.0.2014-05-058.
[5] 张学勇, 王明杰, 李旭丹, 等. 肾脏嫌色细胞癌的影像学分析[J]. 医学影像学杂志, 2018, 28(5): 790-793. CNKI: SUN:XYXZ.0.2018-05-028.
[6] Motzer RJ, Agarwal N, Beard C, et al. NCCN clinical practice guidelines in oncology: kindey cancer[J]. J Natl Compr Canc Netw, 2009, 7(6): 618-630. DOI: 10.6004/jnccn.2009.0043.
[7] Moch H, Artibani W, Delahunt B, et al. Reassessing the current UICC/AJCC TNM staging for renal cell carcinoma[J]. Eur Urol, 2009, 56(4): 636-643. DOI: 10.1016/j.eururo.2009.06.036.
[8] May M, Zigeuner R, Aziz A, et al. Postoperative prognosis of chromophobic renal cell carcinoma: comparative analysis of the multinational CORONA database[J]. Urologe A, 2014, 53(2): 228-235. DOI: 10.1007/s00120-013-3237-y.
[9] Xie YP, Ma X, Li HZ, et al. Prognostic value of clinical and pathological features in Chinese patients with chromophobe renal cell carcinoma: a 10-year single-center study[J]. J Cancer, 2017, 8(17): 3474-3479. DOI: 10.7150/jca.19953.
[10] 黎亚娟, 黄夏玲, 龙莉玲. 增强CT在肾嫌色细胞癌和肾嗜酸细胞腺瘤中的鉴别诊断价值[J]. 微创医学, 2020, 15(2): 177-180. DOI: 10.11864/j.issn.1673.2020.02.14.
[11] MotzerＲJ, Jonasch E, Agarwal N, et al. Kidney cancer, version 2. 2017, NCCN clinical practice guidelines in oncology[J]. J Natl Compr Canc Netw, 2017, 15(6): 804-834. DOI: 10.6004/jnccn.2017.0100.
[12] Kopp RP, Aganovic L, Palazzi KL, et al. Differentiation of clear from non-clear cell renal cell carcinoma using CT washout formula[J]. Can J Urol, 2013, 20(3): 6790-6797. PMID: 23783049.
[13] Rosenkrantz AB, Hindman N, Fitzgerald EF, et al. MRI features of renal oncocytoma and chomaophobe renal cell carcinoma[J]. AJR Am J Roentgenol, 2010, 195(6): 421-427. DOI: 10.2214/AJR.10.4718.
[14] Galmiche C, Bernhard JC, Yacoub M, et al. Is multiparametric MRI useful for differentiating oncocytomas from chromophobe renal cell carcinomas[J]? AJR Am J Roentgenol, 2017, 208(2): 343-350. DOI: 10.2214/AJR.16.16832.
[15] Young JR, Margolis D, Sauk S, et al. Clear cell renal cell carcinoma: discrimination from other renal cell carcinoma subtypes and oncocytoma at multiphasic multidetector CT[J]. Radiology, 2013, 267(2): 444-453. DOI: 10.1148/radiol.13112617.
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