铁死亡介导椎间盘退变的研究进展

doi:10.13418/j.issn.1001-165x.2025.1.16

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中国临床解剖学杂志 ›› 2025, Vol. 43 ›› Issue (1) : 102-106. DOI: 10.13418/j.issn.1001-165x.2025.1.16

综述

铁死亡介导椎间盘退变的研究进展

邓棕元，陈崇，梁国彦，叶勇裕，余正然，余涛，汪露通，梁昌详，昌耘冰*

作者信息 +

Research progress on ferroptosis-mediated intervertebral disc degeneration

Deng Zongyuan, Chen Chong, Liang Guoyan, Ye Yongyu, Yu Zhengran, Yu Tao, Wang Lutong, Liang Changxiang, Chang Yunbing*

Author information +

文章历史 +

摘要

椎间盘退变（intervertebral disc degeneration，IVDD）是脊柱外科常见的病变，常常导致椎管狭窄、椎间盘突出等脊柱退行性疾病，随着年龄的增长，其患病率呈上升趋势。IVDD的发病机制复杂，尚不明确，目前仍无有效治疗药物。铁死亡是一种新型的细胞死亡形式，其特点是铁依赖性的脂质过氧化物的积累，在许多疾病的发展中具有重要作用。近年研究发现，铁死亡与IVDD的发生、发展密切相关，但其在IVDD中的作用机制尚未完全明确。本文现就铁死亡的分子机制、铁死亡与IVDD的关系及其在临床应用潜力方面作一综述，旨在为IVDD的预防及治疗提供新思路。

Abstract

Intervertebral disc degeneration (IVDD) is a common lesion in spinal surgery, which often leads to spinal degenerative diseases such as spinal stenosis and disc herniation. As age increases, its prevalence is on the rise. The pathogenesis of IVDD is complex and unclear, and there are currently no effective treatments. Ferroptosis is a novel form of cell death characterized by the accumulation of iron-dependent lipid peroxides and plays an important role in the development of many diseases. Recent studies have found that ferroptosis is closely related to the occurrence and development of IVDD, but its mechanism of action in IVDD has not yet been fully understood. This article reviewed the molecular mechanism of ferroptosis, the relationship between ferroptosis and IVDD, and its clinical application potential, aiming to provide new ideas for the prevention and treatment of IVDD.

导出引用

邓棕元, 陈崇, 梁国彦, 叶勇裕, 余正然, 余涛, 汪露通, 梁昌详, 昌耘冰. 铁死亡介导椎间盘退变的研究进展[J]. 中国临床解剖学杂志. 2025, 43(1): 102-106 https://doi.org/10.13418/j.issn.1001-165x.2025.1.16

Deng Zongyuan, Chen Chong, Liang Guoyan, Ye Yongyu, Yu Zhengran, Yu Tao, Wang Lutong, Liang Changxiang, Chang Yunbing. Research progress on ferroptosis-mediated intervertebral disc degeneration[J]. Chinese Journal of Clinical Anatomy. 2025, 43(1): 102-106 https://doi.org/10.13418/j.issn.1001-165x.2025.1.16

中图分类号： R681.53

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