目的　观察聚氨酯发泡胶在开颅取脑后新鲜大体标本防腐灌注时的血管止漏和颅盖骨固定效果。  方法    复位颅盖，连续头皮缝合，用扎带沿下颌骨经耳后至颅顶环扎固定，颅内聚氨酯发泡胶填充；行股动脉双向插管，分别采用重力和微型泵灌注，测量颅骨断面漏液量，评价聚氨酯发泡胶对取脑后新鲜大体标本的血管止漏和颅盖骨固定效果。  结果    颅骨断面漏液量占比灌注液总量较低，血管止漏效果显著；干固后的发泡胶紧密粘合颅盖骨，且均匀覆盖颅底各孔裂。  结论    聚氨酯发泡胶在开颅取脑后新鲜大体标本防腐灌注止漏和颅盖骨固定效果理想，对捐献者遗容恢复有利，有助于人脑组织库的建设和发展。

Objective　 To observe the vascular leak prevention and cranial bone fixation effects of polyurethane foam adhesive during the preservation and perfusion of fresh gross specimens after craniotomy. Method    Reset the skull cap, suture the scalp continuously, fix it with a zip tie along the mandible through the ear to the top of the skull, and fill it with intracranial polyurethane foam adhesive; Bilateral catheterization of the femoral artery was performed, and gravity and micro pumps were used for perfusion. The leakage rate of the skull section was measured to evaluate the effectiveness of polyurethane foam adhesive in preventing vascular leakage and fixing the skull cap on fresh gross specimens after removal.   Result   The proportion of skull section leakage to the total perfusion fluid is relatively low, and the effect of vascular leak prevention is significant; After drying, the foam adhesive tightly adheres to the cranial bone and evenly covers all holes and fissures in the skull base.   Conclusion    Polyurethane foam adhesive has an ideal effect on the preservation, perfusion, leak prevention, and fixation of fresh gross specimens after craniotomy, which is beneficial for the recovery of the donor's residual appearance and contributes to the construction and development of the human brain tissue bank.