二甲双胍通过SHH通路对髓母细胞瘤抑制机制的研究进展

章钟鼎, 方黄毅, 盛汉松

中国临床解剖学杂志 ›› 2022, Vol. 40 ›› Issue (4) : 500-502.

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中国临床解剖学杂志 ›› 2022, Vol. 40 ›› Issue (4) : 500-502. DOI: 10.13418/j.issn.1001-165x.2022.4.24
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二甲双胍通过SHH通路对髓母细胞瘤抑制机制的研究进展

  • 章钟鼎1,2,    方黄毅1,2,    盛汉松1,2*
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Research progress on the mechanism of metformin inhibiting medulloblastoma through Sonic Hedgehog pathway

  • Zhang Zhongding1, Fang Huangyi1, Sheng Hansong1,2*
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章钟鼎, 方黄毅, 盛汉松. 二甲双胍通过SHH通路对髓母细胞瘤抑制机制的研究进展[J]. 中国临床解剖学杂志. 2022, 40(4): 500-502 https://doi.org/10.13418/j.issn.1001-165x.2022.4.24
Zhang Zhongding, Fang Huangyi, Sheng Hansong. Research progress on the mechanism of metformin inhibiting medulloblastoma through Sonic Hedgehog pathway[J]. Chinese Journal of Clinical Anatomy. 2022, 40(4): 500-502 https://doi.org/10.13418/j.issn.1001-165x.2022.4.24
中图分类号:      R739.4         

参考文献

[1]  Northcott PA, Robinson GW, Kratz CP, et al. Medulloblastoma[J]. Nat Rev Dis Primers, 2019, 5(1): 11. DOI: 10.1038/s41572-019-0063-6.
[2]  Nüsslein-Volhard C, Wieschaus E. Mutations affecting segment number and polarity in Drosophila[J]. Nature, 1980, 287(5785): 795-801. DOI: 10.1038/287795a0.
[3] Iulianella A, Stanton-Turcotte D. The Hedgehog receptor Patched1 regulates proliferation, neurogenesis, and axon guidance in the embryonic spinal cord[J]. Mech Dev, 2019, 160: 103577. DOI: 10.1016/j.mod.2019.103577.
[4]  Sandulache VC, Hamblin JS, Skinner HD, et al. Association between metformin use and improved survival in patients with laryngeal squamous cell carcinoma[J]. Head Neck, 2014, 36(7): 1039-1043. DOI: 10.1002/hed.23409.
[5]  Khatua S, Song A, Citla Sridhar D, et al. Childhood medulloblastoma: current therapies, emerging molecular landscape and newer therapeutic insights[J]. Curr Neuropharmacol, 2018, 16(7): 1045-1058. DOI: 10.2174/1570159X15666171129111324.
[6] Hall ET, Cleverdon ER, Ogden SK. Dispatching Sonic Hedgehog: molecular mechanisms controlling deployment[J]. Trends Cell Biol, 2019, 29(5): 385-395. DOI: 10.1016/j.tcb.2019.02.005.
[7]  Briscoe J, Thérond PP. The mechanisms of Hedgehog signalling and its roles in development and disease[J]. Nat Rev Mol Cell Biol, 2013, 14(7): 416-429. DOI: 10.1038/nrm3598.
[8] Niewiadomski P, Niedziółka SM, Markiewicz Ł, et al. Gli proteins: regulation in development and cancer[J]. Cells, 2019, 8(2): 147. DOI: 10.3390/cells8020147.
[9] Zhang LG, He XL, Liu XZ, et al. Single-cell transcriptomics in medulloblastoma reveals tumor-initiating progenitors and oncogenic cascades during tumorigenesis and relapse[J]. Cancer Cell, 2019, 36(3): 302-318.e7. DOI: 10.1016/j.ccell.2019.07.009.
[10] Quaglio D, Infante P, Di Marcotullio L, et al. Hedgehog signaling pathway inhibitors: an updated patent review (2015-present)[J]. Expert Opin Ther Pat,2020, 30(4):235-250. DOI: 10.1080/13543776. 2020. 1730327.
[11]Lin ZX, Sheng HS, You CG, et al. Inhibition of the Cyclin D1 promoter in response to Sonic Hedgehog signaling pathway transduction is mediated by Gli1[J]. Exp Ther Med, 2017, 13(1): 307-314. DOI: 10.3892/etm.2016.3969.
[12] Li B, Fei DL, Flaveny CA, et al. Pyrvinium attenuates Hedgehog signaling downstream of smoothened[J]. Cancer Res, 2014, 74(17): 4811-4821. DOI: 10.1158/0008-5472.CAN-14-0317.
[13] Podhorecka M, Ibanez B, Dmoszyńska A. Metformin- its potential anti-cancer and anti-aging effects[J]. Postepy Hig Med Dosw (Online), 2017, 71(0): 170-175. DOI: 10.5604/01.3001.0010.3801.
[14] Carling D. AMPK signalling in health and disease[J]. Curr Opin Cell Biol, 2017, 45: 31-37. DOI: 10.1016/j.ceb.2017.01.005.
[15] Rena G, Hardie DG, Pearson ER. The mechanisms of action of metformin[J]. Diabetologia, 2017, 60(9): 1577-1585. DOI: 10.1007/s00125-017-4342-z.
[16] Zhang Y, Wang Y, Bao C, et al. Metformin interacts with AMPK through binding to gamma subunit[J]. Mol Cell Biochem, 2012, 368(1-2): 69-76. DOI: 10.1007/s11010-012-1344-5.
[17] Lin ZX, Li SS, Sheng HS, et al. Suppression of GLI sensitizes medulloblastoma cells to mitochondria-mediated apoptosis[J]. J Cancer Res Clin Oncol, 2016, 142(12): 2469-2478. DOI: 10.1007/s00432-016-2241-1.
[18] Li YH, Luo J, Mosley Y-Yi c, et al. AMP-activated protein kinase directly phosphorylates and destabilizes hedgehog pathway transcription factor Gli1 in medulloblastoma[J]. Cell Rep, 2015, 12(4): 599-609. DOI: 10.1016/j.celrep.2015.06.054.
[19] Di Magno L, Basile A, Coni S, et al. The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint[J]. Oncotarget, 2016, 7(8): 9538-9549. DOI: 10.18632/oncotarget.7070.
[20] Saxton RA, Sabatini DM. mTOR signaling in growth, metabolism, and disease[J]. Cell, 2017,168(6): 960-976. DOI: 10.1016/j.cell.2017. 02.004.
[21] Wang Y, Ding Q, Yen CJ, et al. The crosstalk of mTOR/S6K1 and Hedgehog pathways[J]. Cancer Cell, 2012, 21(3): 374-387. DOI: 10.1016/j.ccr.2011.12.028.
[22] Elgendy M, Cirò M, Hosseini A, et al. Combination of hypoglycemia and metformin impairs tumor metabolic plasticity and growth by modulating the PP2A-GSK3beta-MCL-1 axis[J]. Cancer Cell, 2019, 35(5): 798-815.e5. DOI: 10.1016/j.ccell.2019.03.007.
[23] Fan C, Wang YS, Liu ZM, et al. Metformin exerts anticancer effects through the inhibition of the Sonic Hedgehog signaling pathway in breast cancer[J]. Int J Mol Med, 2015, 36(1): 204-214. DOI: 10.3892/ijmm.2015.2217.
[24] Song Z, Wei B, Lu CR, et al. Metformin suppresses the expression of Sonic Hedgehog in gastric cancer cells[J]. Mol Med Rep, 2017, 15(4): 1909-1915. DOI: 10.3892/mmr.2017.6205.
[25] Gonnissen A, Isebaert S, Mckee CM, et al. The effect of metformin and GANT61 combinations on the radiosensitivity of prostate cancer cells[J]. Int J Mol Sci, 2017, 18(2): 399. DOI: 10.3390/ijms18020399.
[26] 赵彬. 二甲双胍调节脑胶质瘤周围脑水肿的机制研究[D]. 长春: 吉林大学, 2016.
[27]Di Magno L, Manni S, Di Pastena F, et al. Phenformin inhibits Hedgehog-dependent tumor growth through a complex I-independent redox/corepressor module[J]. Cell Rep, 2020, 30(6): 1735-1752.e7. DOI: 10.1016/j.celrep.2020.01.024.
[28] Arnoux I, Willam M, Griesche N, et al. Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease[J]. Elife, 2018, 7: e38744. DOI: 10.7554/eLife.38744.

基金

浙江省卫生健康科技计划(2021KY794); 温州市基础性科研计划(Y2020419)

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