目的 利用颅脑超声技术评估PIVH对VLBW早产儿小脑生长发育的影响。 方法 选取200例胎龄25~31+6周VLBW早产儿，分为有PIVH组67例，无PIVH组133例，比较两组早产儿体重、头围、小脑横径、蚓部高度、前后径、周长和面积的差异。 结果 纠正胎龄至足月时，有PIVH的早产儿小脑横径、蚓部高度、前后径、周长和面积均低于无PIVH的早产儿（P<0.05），体重（P=0.31）和头围（P=0.462）无显著性差异；亚组分析中，Ⅲ、Ⅳ度PIVH早产儿的小脑横径低于Ⅰ、Ⅱ度PIVH早产儿（P=0.012），体重、头围、小脑蚓部高度、前后径、周长和面积均无显著性差异。 结论 PIVH可能对VLBW早产儿小脑生长发育有显著影响，特别是PIVH严重的早产儿，小脑横径比其他指标受影响更大。
Abstract
Objective To assess the effect of PIVH on the cerebellar development in VLBW premature infants by means of cranial ultrasound. Methods Two hundred VLBW premature infants with gestational age 25 to 31+6 weeks were enrolled and divided into with a PIVH group (n=67), and a without PIVH group (n=133). The differences in transverse cerebellar diameter, vermis height, vermis diameter, vermis circumference and vermis area between the two groups were compared. Results Transverse cerebellar diameter, vermis height, vermis diameter, vermis circumference and vermis area of preterm infants in the PIVH group were significantly lower than those of preterm ones in the without PIVH group at term equivalent age (P<0.05). There was no significant difference in weight (P=0.31) and head circumference (P=0.462). In subgroup analysis, Transverse cerebellar diameter of the preterm infants with grades Ⅲ、Ⅳ PIVH was significantly lower than those of preterm ones with grades Ⅰ、Ⅱ PIVH (P=0.012). There were no significant difference in weight, head circumference, vermis height, vermis diameter, vermis circumference and vermis between these subgroups. Conclusions PIVH may have a significant impact on cerebellar development in VLBW premature infants, especially those with a severe PIVH. The transverse cerebellar diameter is more affected than other indicators.
关键词
小脑 /
超声 /
早产儿 /
脑室周围-脑室内出血
Key words
Cerebellum /
Cranial ultrasound /
Premature infant /
Periventricular-intraventricular hemorrhages
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基金
2020年度河北省医学科学研究课题计划（20200173）
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