目的 构建轻度青少年特发性脊柱侧凸患者的有限元模型,验证该模型的有效性,并进行有限元分析。 方法 建立1例轻度青少年特发性脊柱侧凸患者第6颈椎至第5腰椎的有限元模型,从几何形态及力学两方面对该模型进行有效性验证。分析该有限元模型在模拟前屈、后伸、左侧屈、右侧屈、左旋转、右旋转6种运动状态下,各椎体的应力变化。 结果 成功构建了轻度青少年特发性脊柱侧凸患者的有限元模型,模型总节点数为2561811个,总单元数为1547806个,并验证了该模型有效。模拟后伸、旋转活动时,畸形最明显处的椎体应力变化趋势与静态时相反。 结论 本实验所构建的轻度青少年特发性脊柱侧凸有限元模型有效,可进一步用于该疾病的相关研究。
Abstract
Objective To establish a finite element model of mild adolescent idiopathic scoliosis(AIS) patients, to verify the model, and to perform finite element analysis. Methods A finite element model of the mild AIS patient from the sixth cervical vertebrae to the fifth lumbar vertebrae was constructed. The model from two aspects of geometry and mechanics was verified. The stress changes of each vertebral body were simulated under movements of forward flexion, backward extension, left flexion, right flexion, left rotation and right rotation. Results A finite element model of the mild AIS patient has been established. The total number of nodes and total elements were 2561811 and 1547806, respectively. The validity of the model has been verified. The stress changes of the vertebral body in the most obvious deformity was opposite to that in the static state when simulating backward extension and rotation. Conclusions The finite element model of mild AIS is effective and can be further used for the research on the disease.
关键词
青少年 /
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  /
特发性脊柱侧凸 /
有限元模型 /
有效性验证 /
有限元分析
Key words
Adolescent /
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Idiopathic scoliosis /
Finite element model /
Validation /
Finite element analysis
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参考文献
[1] Fan HW, Huang ZF, Wang QF, et al. Prevalence of idiopathic scoliosis in Chinese schoolchildren: a large, population-based study[J]. Spine (Phila Pa 1976), 2016, 41(3): 259-264. DOI: 10.1097/BRS. 0000000000001197.
[2] Ogilvie JW, Braun J, Argyle V, et al. The search for idiopathic scoliosis genes[J]. Spine (Phila Pa 1976), 2006, 31(6): 679-681. DOI: 10.1097/01.brs.0000202527.25356.90.
[3] Salehi LB, Mangino M, Serio SD, et al. Assignment of a locus for autosomal dominant idiopathic scoliosis (IS) to human chromosome 17p11[J]. Hum Genet, 2002, 111(4-5): 401-404. DOI: 10.1007/s00439-002-0785-4.
[4] Justice CM, Miller NH, Marosy B, et al. Familial idiopathic scoliosis: evidence of an X-linked susceptibility locus[J]. Spine, 2003, 28(6): 589-594. DOI: 10.1097/01.BRS.0000049940.39801.E6.
[5] Cheung J, Halbertsma JP, Veldhuizen AG, et al. A preliminary study on electromyographic analysis of the paraspinal musculature in idiopathic scoliesis[J]. Eur Spine J, 2005, 14(2): 130-137. DOI: 10.1007/s00586-004-0780-7.
[6] Asher MA, Buton DC. A concept of idiopathic scoliosis deformities as imperfect torsion(s)[J]. Clin Orthop Relat Res, 1999, 364(7): 11-25. DOI: 10.1097/00003086-199907000-00003.
[7] 孙光权, 邱勇, 黄爱兵, 等. 青少年特发性脊柱侧凸患者软骨细胞中褪黑素受体的表达量[J]. 中国脊柱脊髓杂志, 2009, 19(3): 227-230. DOI: 10.3969/j.issn.1004-406X.2009.03.12.
[8] Cheng JC, Qin L, Cheung CS, et al. Generalized low areal and volumetric bone mineral density in adolescent idiopathic scoliosis[J]. J Bone Miner Res, 2000, 15(8): 1587-95. DOI: 10.1359/jbmr. 2000. 15.8.158.7.
[9] Liu T, Chu WC, Young G, et al. MR analysis of regional brain volume in adolescent idiopathic scoliosis: neurological manifestation of a systemic disease[J]. J Mag Res Imag, 2008, 27(4):732-736. DOI: 10.1002/jmri.21321.
[10]王智伟, 邱旭升, 王渭君, 等. 青少年特发性脊柱侧凸交感神经系统活性左右侧对称性的观察[J]. 中国脊柱脊髓杂志, 2014, 24(10): 923-927. DOI: 10.3969/j.issn.1004-406X.2014.10.11.
[11] 朱立新, 王健, 曹延林, 等. 腰椎峡部裂机翼型记忆合金固定装置的有限元分析[J]. 中国临床解剖学杂志, 2012, 30(3): 333-336, 341. DOI: 10.13418/j.issn.1001-165x.2012.03.024.
[12]Busscher I,van Dieën JH,Kingma I,et al.Biomechanical characteristics of different regions of the human spine[J]. Spine (Phila Pa 1976), 2009, 34(26): 2858-2864. DOI: 10.1097/BRS. 0b013e318 1b4c75d.
[13] Zander T, Rohlmann A, Calisse J, et al. Estimation of muscle forces in the lumbar spine during upper-body inclination[J]. Clin Biomecc (Brastol-Avon), 2001, 16(1): 73-80. DOI: 10.1016/S0268-0033(00)00108-X.
[14] Watkins R 4th, Watkins R 3rd, Williams L, et al. Stability provided by the sternum and rib cage in the thoracic spine[J]. Spine (Phila Pa 1976), 2005, 30(11): 1283-1286. DOI: 10.1097/01.brs.0000164257.69354.bb.
[15] 范宁, 藏磊, 海涌, 等. 脊柱侧凸有限元建模方法的应用进展[J]. 中国骨伤,2018,31(4):391-394. DOI:10.3969/j.issn.1003-0034.2018. 04.018.
基金
国家自然科学基金(3177070377);广州市科技计划项目(201704020069)