目的 从肠道菌群和免疫炎症调控的角度，探讨润燥止痒胶囊（Runzao Zhiyang capsule，RZC）对银屑病样皮损的药效作用。 方法 研究RZC给药对银屑病样皮损模型大鼠的作用，检测血清中细胞炎症因子（IL-6和TNF-α、IL-17和IL-10）水平，分析模型大鼠粪便重要菌落的数量。 结果 给药RZC两周后，显著改善模型大鼠的银屑病样皮损症状。RZC下调血清IL-6、TNF-α和IL-17含量，上调IL-10水平，提示对机体炎症反应的缓解作用。给药降低模型大鼠肠道的肠杆菌和肠球菌的含量，提高乳酸杆菌和双歧杆菌的数目。 结论 RZC治疗银屑病样皮损可能与其调控肠道菌群结构，缓解宿主免疫炎症反应有关。
Abstract
Objective To explore the effects of Runzao Zhiyang capsule (RZC) on psoriatic lesions from the perspective of regulation on gut microbiota and immune inflammation. Methods Effect of RZC on rat model with psoriatic lesions was studied. Levels of inflammatory cytokines (IL-6、TNF-α、IL-17 and IL-10) in the plasma were detected. The number of major bacterial colonies in feces was analyzed. Results After treatment with RZC for two weeks, symptoms of psoriatic lesions in rats were significantly improved. The levels of IL-17, IL-6, and TNF-α in the plasma were down-regulated by RZC, but the IL-10 level was up-regulated by RZC, respectively, which indicating the amelioration of inflammatory response. RZC also reduced the amounts of escherichia and enterococcus, and increased the number of lactobacillus and bifidobacteria in the gut. Conclusions RZC treats psoriatic lesions, which maybe related to modulating gut microbial structure, and ameliorating immune inflammatory response of the host.
关键词
润燥止痒胶囊 /
银屑病样皮损 /
肠道菌群 /
炎症反应
Key words
Runzao Zhiyang capsule; /
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Psoriatic lesion; /
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Gut microbiota; /
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Inflammatory response
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基金
中国博士后科学基金项目资助（2019TQ0140，2019M663013）
京ICP备08002354号-3
